Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer
Abstract
Despite aptamers are very promising alternative to antibodies, very few of them are under clinical trials or are used as drugs. Among them, NU172 is currently in Phase II as anticoagulant in heart disease treatments. It inhibits thrombin activity much more effectively than TBA, the best-known thrombin binding aptamer. The crystal structure of thrombin-NU172 complex reveals a bimodular duplex/quadruplex architecture for the aptamer, which binds...
Paper Details
Title
Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer
Published Date
Oct 24, 2018
Journal
Volume
46
Issue
22
Pages
12177 - 12185
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