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Valeria Napolitano
University of Naples Federico II
4Publications
3H-index
26Citations
Publications 4
Newest
#1R. Troisi (University of Naples Federico II)H-Index: 1
#2Valeria Napolitano (University of Naples Federico II)H-Index: 3
Last.Filomena Sica (University of Naples Federico II)H-Index: 24
view all 5 authors...
#1Irene Russo Krauss (University of Naples Federico II)H-Index: 14
#2Valeria Napolitano (University of Naples Federico II)H-Index: 3
Last.Filomena Sica (University of Naples Federico II)H-Index: 24
view all 7 authors...
Abstract Recently, mixed duplex/quadruplex oligonucleotides have attracted great interest for use as biomedical aptamers. In the case of anti-thrombin aptamers, the addition of duplex-forming sequences to a G-quadruplex module identical or very similar to the best-known G-quadruplex of the Thrombin Binding Aptamer (HD1) results in new or improved biological properties, such as higher activity or different recognition properties with respect to HD1. Remarkably, this bimodular fold was hypothesize...
#1Irene Russo Krauss (University of Naples Federico II)H-Index: 14
#2V. A. Spiridonova (MSU: Moscow State University)H-Index: 10
Last.Filomena Sica (University of Naples Federico II)H-Index: 24
view all 5 authors...
Mixed duplex/quadruplex oligonucleotides have attracted great interest as therapeutic targets as well as effective biomedical aptamers. In the case of thrombin-binding aptamer (TBA), the addition of a duplex motif to the G-quadruplex module improves the aptamer resistance to biodegradation and the affinity for thrombin. In particular, the mixed oligonucleotide RE31 is significantly more effective than TBA in anticoagulation experiments and shows a slower disappearance rate in human plasma and bl...
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