Development of Continuous Spherical Crystallization to Prepare Fenofibrate Agglomerates with Impurity Complexation Using Mixed-Suspension, Mixed-Product Removal Crystallizer

Agglomeration during crystallization, such as spherical crystallization, has the potential to integrate pharmaceutical downstream processes after compound synthesis. This process incorporates granulation and agglomeration during the crystallization process and to date has been performed in batch reactors. However, because it involves certain complicated phenomena, the batch process is difficult to scale up for commercial production. We...