Match!
Hirofumi Takeuchi
Gifu Pharmaceutical University
Organic chemistryLiposomeChemistrySolventChromatography
306Publications
49H-index
9,278Citations
What is this?
Publications 274
Newest
#1Yoshiko Takeuchi (Gifu Pharmaceutical University)H-Index: 5
#2Tomoka Nishimatsu (Gifu Pharmaceutical University)
Last. Hirofumi Takeuchi (Gifu Pharmaceutical University)H-Index: 49
view all 4 authors...
Abstract The most important issue in the design of orally disintegrating films (ODFs) is the control of the ODFs' disintegration properties. A better understanding of the mechanisms of ingredients used to promote or disturb the disintegration time of ODFs would improve the development of ODF formulations. Here we focused on the advantage of adding insoluble particles (IPs) to improve the disintegration times of ODFs. We also verified the undesirable impact of the use of IPs on the mechanical pro...
Source
#1Yuichi Okubo (Gifu Pharmaceutical University)
#2Yoshiko Takeuchi (Gifu Pharmaceutical University)H-Index: 5
Last. Hirofumi Takeuchi (Gifu Pharmaceutical University)H-Index: 49
view all 6 authors...
Source
#1Misa Naganuma (Gifu Pharmaceutical University)H-Index: 5
#2Kohei Tahara (Gifu Pharmaceutical University)H-Index: 17
Last. Mitsuhiro Nakamura (Gifu Pharmaceutical University)H-Index: 18
view all 14 authors...
Objectives:Paclitaxel is a highly effective antitumor agent with notable adverse events, including hypersensitivity reactions, peripheral neuropathy, arthralgia, myalgias, and neutropenia. Solvent-...
Source
Source
#1Yoshiko Takeuchi (Gifu Pharmaceutical University)H-Index: 5
#2Misaki Kawamoto (Gifu Pharmaceutical University)H-Index: 1
Last. Hirofumi Takeuchi (Gifu Pharmaceutical University)H-Index: 49
view all 4 authors...
Abstract In the design of the orally disintegrating films (ODFs), it is important to determine the disintegration time (DT) precisely and properly. These films’ DTs are usually assessed by a disintegration test defined in the pharmacopoeias, but under the conditions of such tests, a much larger volume of water is used and a stronger up-down movement is applied compared to the conditions of the human oral cavity. Here we developed and tested our new disintegration test system for ODFs. We chose a...
1 CitationsSource
#1Takuma ObaH-Index: 1
#2Kohei Tahara (Gifu Pharmaceutical University)H-Index: 17
Last. Hirofumi Takeuchi (Gifu Pharmaceutical University)H-Index: 49
view all 6 authors...
Abstract Porous materials are attractive substances for designing pharmaceutical particulates. However, understanding the behavior of liquid absorption into the intra-pores and interstices of porous carrier particles is important to effectively manufacture active pharmaceutical ingredients (APIs) using these carriers. In this study, we established a simple and practical method for evaluating the liquid absorption behavior of porous carriers using force tensiometry and a capillary rise technique....
1 CitationsSource
#1Kohei Tahara (Gifu Pharmaceutical University)H-Index: 17
#2Yuichi Kono (Gifu Pharmaceutical University)
Last. Hirofumi Takeuchi (Gifu Pharmaceutical University)H-Index: 49
view all 4 authors...
Agglomeration during crystallization, such as spherical crystallization, has the potential to integrate pharmaceutical downstream processes after compound synthesis. This process incorporates granulation and agglomeration during the crystallization process and to date has been performed in batch reactors. However, because it involves certain complicated phenomena, the batch process is difficult to scale up for commercial production. We demonstrate the feasibility of a continuous process of cryst...
Source
#1Yoshiko Takeuchi (Gifu Pharmaceutical University)H-Index: 5
#2Tomoka Tomita (Gifu Pharmaceutical University)H-Index: 2
Last. Hirofumi Takeuchi (Gifu Pharmaceutical University)H-Index: 49
view all 8 authors...
Abstract In the manufacture of tablets, especially in direct tableting processes, the flowability of excipient powders and formulated powders is one of the most important characteristics. In the past two decades, orally disintegrating tablets (ODTs) have been prepared as popular solid dosage forms for elderly patients. Many types of mannitol granules have been developed and marketed as new pharmaceutical excipients for ODTs, owing to the solubility and palatability of mannitol. Characterizing th...
3 CitationsSource
#1Yoshiko Takeuchi (Gifu Pharmaceutical University)H-Index: 5
#2Kaori Umemura (Gifu Pharmaceutical University)H-Index: 1
Last. Hirofumi Takeuchi (Gifu Pharmaceutical University)H-Index: 49
view all 4 authors...
Abstract Hydroxypropyl cellulose (HPC) is a water-soluble polymer used as a binder during pharmaceutical tableting and granulation. HPC is also known as a base material for pharmaceutical film by virtue of its film formability with excellent plasticity. The aim of this study was to assess the applicability of HPC to orally disintegrating film (ODF) and to investigate optimization of the ODF formulation of HPC. The effects of the molecular weight of HPC and the addition of active pharmaceutical i...
3 CitationsSource
#1Kohei Tahara (Gifu Pharmaceutical University)H-Index: 17
#2Manami Kobayashi (Gifu Pharmaceutical University)H-Index: 1
Last. Hirofumi Takeuchi (Gifu Pharmaceutical University)H-Index: 49
view all 6 authors...
Abstract In this study, we demonstrated that cationic liposomes with incorporated stearylamine (SA) inhibit viral infectivity without preloaded active pharmaceutical ingredients. Specifically, we correlated physiochemical properties of liposomes, such as zeta potentials and particle sizes, with virus infectivity using the BacMam™ reagent, which is based on recombinant baculovirus (BV). Compared with neutral or negatively-charged liposomes, SA liposomes suppressed BV infectivity in several mammal...
3 CitationsSource
12345678910