Effect of Intensive Blood Pressure Lowering on Kidney Tubule Injury: Findings From the ACCORD Trial Study Participants

Rationale & Objective Random assignment to intensive blood pressure (BP) lowering (systolic BP < 120 mm Hg) compared to a less intensive BP target (systolic BP < 140 mm Hg) in the Action to Control Cardiovascular Risk in Diabetes BP (ACCORD-BP) trial resulted in a more rapid decline in estimated glomerular filtration rate (eGFR). Whether this reflects hemodynamic effects or intrinsic kidney damage is unknown. Study Design Longitudinal analysis...