Original paper
UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis
Abstract
The majority (90%–95%) of amyotrophic lateral sclerosis (ALS) is sporadic, and ∼50% of patients develop symptoms of frontotemporal degeneration (FTD) associated with shorter survival. The genetic polymorphism rs12608932 in UNC13A confers increased risk of sporadic ALS and sporadic FTD and modifies survival in ALS. Here, we evaluate whether rs12608932 is also associated with frontotemporal disease in sporadic ALS. We identified reduced cortical...
Paper Details
Title
UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis
Published Date
Jan 1, 2019
Journal
Volume
73
Pages
190 - 199
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Notes
History