Proinsulin-mediated induction of type 1 diabetes in HLA-DR4-transgenic mice
Abstract
Antigen-specific immunotherapy of autoimmune disease currently remains the only potentially curative approach. However, translation of promising pre-clinical results into successful clinical application has proven challenging. In part, this is because pre-clinical findings in mouse models have to be redesigned for human application due to differences in MHC II. To reduce the gap between pre-clinical and clinical studies, we have created a novel...
Paper Details
Title
Proinsulin-mediated induction of type 1 diabetes in HLA-DR4-transgenic mice
Published Date
Sep 20, 2018
Journal
Volume
8
Issue
1
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