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Mark Peakman
King's College London
333Publications
52H-index
8,909Citations
Publications 333
Newest
Published on Jan 1, 2019in Schizophrenia Bulletin 6.94
Thomas Pollak11
Estimated H-index: 11
(King's College London),
Jonathan P Rogers1
Estimated H-index: 1
(King's College London)
+ 4 AuthorsPhilip McGuire105
Estimated H-index: 105
(King's College London)
2 Citations Source Cite
Published on Jan 9, 2019
Iria Gomez-Tourino6
Estimated H-index: 6
,
Yogesh Kamra1
Estimated H-index: 1
+ 2 AuthorsMark Peakman52
Estimated H-index: 52
Published on Jan 1, 2019in The Lancet Diabetes & Endocrinology 19.31
Bart O. Roep58
Estimated H-index: 58
(City of Hope National Medical Center),
Daniel C S Wheeler1
Estimated H-index: 1
(King's College London),
Mark Peakman52
Estimated H-index: 52
(HealthPartners)
Summary Precision medicine has emerged as a mantra for therapeutic approaches to complex diseases. The defining concept relies on a detailed insight into disease pathogenesis and therapeutic mechanism. Although the type 1 diabetes field has gained new insights into disease endotypes and indications of efficacy for several therapies, none of these is yet licensed, partly because of immune suppressive side-effects beyond control of islet autoimmunity. New strategies designed to regulate the immune...
4 Citations Source Cite
Published on Jan 1, 2019in The Lancet Diabetes & Endocrinology 19.31
Mark A. Atkinson82
Estimated H-index: 82
(University of Florida),
Bart O. Roep58
Estimated H-index: 58
(City of Hope National Medical Center)
+ 2 AuthorsMark Peakman52
Estimated H-index: 52
(HealthPartners)
Summary With the conceptual advance about four decades ago that type 1 diabetes represents an autoimmune disease, hope arose that immune-based therapies would soon emerge to prevent and reverse the disorder. However, despite dozens of clinical trials seeking to achieve these goals, the promise remains unfulfilled, at least in a pragmatic form. With the benefit of hindsight, several important reasons are likely to account for this disappointing outcome, including failure to appreciate disease het...
1 Citations Source Cite
Published on May 1, 2019in International Journal of Pharmaceutics 3.86
M. Dul (Cardiff University), Tatjana Nikolic11
Estimated H-index: 11
(Leiden University Medical Center)
+ 12 AuthorsMark Peakman52
Estimated H-index: 52
Abstract Antigen specific immunotherapy aims to tolerise patients to specific autoantigens that are responsible for the pathology of an autoimmune disease. Immune tolerance is generated in conditions where the immune response is suppressed and thus gold nanoparticles (AuNPs) are an attractive drug delivery platform due to their anti-inflammatory effects and their potential to facilitate temporal and spatial delivery of a peptide autoantigen in conjunction with pro-tolerogenic elements. In this s...
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Published on Apr 1, 2018in BMJ Open 2.41
Vassiliki Bravis6
Estimated H-index: 6
(Imperial College London),
Akaal Kaur1
Estimated H-index: 1
(Imperial College London)
+ 9 AuthorsMark Peakman52
Estimated H-index: 52
(King's College London)
Objectives To describe the characteristics of children and adults with incident type 1 diabetes in contemporary, multiethnic UK, focusing on differences between the islet autoantibody negative and positive. Design Observational cohort study. Setting 146 mainly secondary care centres across England and Wales. Participants 3312 people aged ≥5 years were recruited within 6 months of a clinical diagnosis of type 1 diabetes via the National Institute for Health Research Clinical Research Network. 302...
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Published on Dec 1, 2018in Scientific Reports 4.12
Johan Verhagen1
Estimated H-index: 1
(Guy's Hospital),
Emma L. Smith1
Estimated H-index: 1
(UCB)
+ 2 AuthorsMark Peakman52
Estimated H-index: 52
(HealthPartners)
Antigen-specific immunotherapy of autoimmune disease currently remains the only potentially curative approach. However, translation of promising pre-clinical results into successful clinical application has proven challenging. In part, this is because pre-clinical findings in mouse models have to be redesigned for human application due to differences in MHC II. To reduce the gap between pre-clinical and clinical studies, we have created a novel mouse model that expresses human HLA-DR4, but no en...
1 Citations Source Cite
Published on Feb 28, 2018in Frontiers in Immunology 5.51
Emma L. Smith1
Estimated H-index: 1
(UCB),
Mark Peakman52
Estimated H-index: 52
(King's College London)
Autoimmune and allergic diseases occur when an individual mounts an inappropriate immune response to a self-antigen, or an innocuous environmental antigen. This triggers a pathogenic T cell response resulting in damage to specific tissues and organs. In type one diabetes this manifests as destruction of the insulin-secreting  cells, resulting in a life-long dependency on recombinant insulin. Modulation of the pathogenic T cell response with antigen-specific peptide immunotherapy offers the pote...
8 Citations Source Cite
Published on Apr 1, 2018in Journal of Immunology 4.54
Cristina Rius3
Estimated H-index: 3
(Cardiff University),
Meriem Attaf7
Estimated H-index: 7
(Cardiff University)
+ 12 AuthorsInge Marie Svane34
Estimated H-index: 34
Peptide-MHC (pMHC) multimers, usually used as streptavidin-based tetramers, have transformed the study of Ag-specific T cells by allowing direct detection, phenotyping, and enumeration within polyclonal T cell populations. These reagents are now a standard part of the immunology toolkit and have been used in many thousands of published studies. Unfortunately, the TCR-affinity threshold required for staining with standard pMHC multimer protocols is higher than that required for efficient T cell a...
8 Citations Source Cite
Published on Aug 1, 2018in Journal of Clinical Investigation 13.25
Lorraine Yeo3
Estimated H-index: 3
,
Alyssa Woodwyk1
Estimated H-index: 1
(Western Michigan University)
+ 13 AuthorsGarry Dolton16
Estimated H-index: 16
(Cardiff University)
In type 1 diabetes, cytotoxic CD8+ T cells with specificity for β cell autoantigens are found in the pancreatic islets, where they are implicated in the destruction of insulin-secreting β cells. In contrast, the disease relevance of β cell–reactive CD8+ T cells that are detectable in the circulation, and their relationship to β cell function, are not known. Here, we tracked multiple, circulating β cell–reactive CD8+ T cell subsets and measured β cell function longitudinally for 2 years, starting...
5 Citations Source Cite
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