Roles of PAD4 and netosis in experimental atherosclerosis and arterial injury: Implications for superficial erosion

Aim: Neutrophils likely contribute to the thrombotic complications of human atheromata. In particular, neutrophil extracellular traps (NETs) could exacerbate local inflammation and amplify and propagate arterial intimal injury and thrombosis. Peptidyl arginine deiminase 4 (PAD4) participates in NET formation, but understanding of this enzyme’s role in atherothrombosis remains scant. This study tested the hypothesis that PAD4 and NETs influence...