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Electrical Stimulation Prevents Preferential Skeletal Muscle Myosin Loss in Steroid-Denervation Rats

Published on Aug 10, 2018in Frontiers in Physiology3.201
· DOI :10.3389/fphys.2018.01111
Takashi Yamada26
Estimated H-index: 26
(RMIT: RMIT University),
Koichi Himori5
Estimated H-index: 5
(RMIT: RMIT University)
+ 10 AuthorsJohanna T. Lanner17
Estimated H-index: 17
(KI: Karolinska Institutet)
Abstract
Severe muscle weakness concomitant with preferential depletion of myosin has been observed in several pathological conditions. Here we used the steroid-denervation (S-D) rat model, which shows dramatic decrease in myosin content and force production, to test whether electrical stimulation (ES) treatment can prevent these deleterious changes. S-D was induced by cutting the sciatic nerve and subsequent daily injection of dexamethasone for 7 days. For ES treatment, plantarflexor muscles were electrically stimulated to produce four sets of five isometric contractions each day. Plantarflexor in situ isometric torque, muscle weight, skinned muscle fiber force, and protein and mRNA expression were measured after the intervention period. ES treatment partly prevented the S-D-induced decreases in plantarflexor in situ isometric torque and muscle weight. ES treatment fully prevented S-D-induced decreases in skinned fiber force and ratio of myosin heavy chain (MyHC) to actin, as well as increases in the reactive oxygen/nitrogen species-generating enzymes NADPH oxidase (NOX) 2 and 4, phosphorylation of p38 MAPK, mRNA expression of the muscle-specific ubiquitin ligases muscle ring finger-1 (MuRF-1) and atrogin-1, and autolyzed active calpain-1. Thus, ES treatment is an effective way to prevent muscle impairments associated with loss of myosin.
  • References (47)
  • Citations (2)
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References47
Newest
#1Oliver Friedrich (FAU: University of Erlangen-Nuremberg)H-Index: 34
#2S. Diermeier (FAU: University of Erlangen-Nuremberg)H-Index: 1
Last. Lars Larsson (KI: Karolinska Institutet)H-Index: 48
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Intensive care interventions involve periods of mechanical ventilation, sedation and complete mechanical silencing of patients. Critical illness myopathy (CIM) is an ICU-acquired myopathy that is associated with limb muscle weakness, muscle atrophy, electrical silencing of muscle and motor proteinopathy. The hallmark of CIM is a preferential muscle myosin loss due to increased catabolic and reduced anabolic activity. The ubiquitin proteasome pathway plays an important role, apart from recently i...
6 CitationsSource
#1Koichi Himori (RMIT: RMIT University)H-Index: 5
#2Daisuke Tatebayashi (RMIT: RMIT University)H-Index: 5
Last. Takashi Yamada (RMIT: RMIT University)H-Index: 26
view all 7 authors...
Skeletal muscle weakness is a prominent feature in patients with rheumatoid arthritis (RA). In this study, we investigated whether neuromuscular electrical stimulation (NMES) training protects against skeletal muscle dysfunction in rats with adjuvant-induced arthritis (AIA). AIA was produced by intraarticular injection of complete Freund’s adjuvant into the knees of Wistar rats. For NMES training, dorsiflexor muscles were stimulated via a surface electrode (0.5 ms pulse, 50 Hz, 2 s on/4 s off). ...
4 CitationsSource
To investigate time-dependent changes in sarcoplasmic reticulum (SR) Ca2+ release and myofibrillar (my-) Ca2+ sensitivity during recovery from prolonged low-frequency force depression (PLFFD), rat gastrocnemius muscles were electrically stimulated in situ. After 0 h (R0), 0.5 h (R0.5), 2 h (R2), 6 h (R6), or 12 h of recovery, the superficial gastrocnemius muscles were excised and used for biochemical and skinned fiber analyses. At R0, R0.5, R2, and R6, the ratio of force at 1 Hz to that at 50 Hz...
10 CitationsSource
#1Scott K. Powers (UF: University of Florida)H-Index: 77
#2Aaron B. Morton (UF: University of Florida)H-Index: 10
Last. Ashley J. Smuder (UF: University of Florida)H-Index: 30
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Skeletal muscles comprise the largest organ system in the body and play an essential role in body movement, breathing, and glucose homeostasis. Skeletal muscle is also an important endocrine organ that contributes to the health of numerous body organs. Therefore, maintaining healthy skeletal muscles is important to support overall health of the body. Prolonged periods of muscle inactivity (e.g., bed rest or limb immobilization) or chronic inflammatory diseases (i.e., cancer, kidney failure, etc....
51 CitationsSource
#1Monica Llano-Diez (KI: Karolinska Institutet)H-Index: 2
#2Arthur J. Cheng (KI: Karolinska Institutet)H-Index: 16
Last. Joseph D. Bruton (KI: Karolinska Institutet)H-Index: 37
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Background Critical illness myopathy is an acquired skeletal muscle disorder with severe myosin loss and muscle weakness frequently seen in intensive care unit (ICU) patients. It is unknown if impaired excitation-contraction coupling contributes to the muscle weakness.
9 CitationsSource
#1Toshinori Yoshihara (Juntendo University)H-Index: 11
#2Shuichi Machida (Juntendo University)H-Index: 10
Last. Hisashi Naito (Juntendo University)H-Index: 30
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The study described herein aimed to examine changes in HDAC4 and its downstream targets in immobilization-induced rat skeletal muscle atrophy. Eleven male Wistar rats were used, and one hindlimb was immobilized in the plantar flexion position using a plaster cast. The contralateral, non-immobilized leg served as an internal control. After 10 days, the gastrocnemius muscles were removed from both hindlimbs. Ten days of immobilization resulted in a significant reduction (−27.3 %) in gastrocnemius ...
12 CitationsSource
#1Lorenza Brocca (UNIPV: University of Pavia)H-Index: 17
#2Emanuela Longa (UNIPV: University of Pavia)H-Index: 8
Last. Roberto Bottinelli (UNIPV: University of Pavia)H-Index: 53
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Key points It is generally assumed that muscle fibres go through atrophy following disuse with a loss of specific force and an increase in unloaded shortening velocity. However, the underlying mechanisms remain to be clarified. Most studies have focused on events taking place during the development of disuse, whereas the subsequent recovery phase, which is equally important, has received little attention. Our findings support the hypotheses that the specific force of muscle fibres decreased foll...
17 CitationsSource
#1Marco Alessandro Minetto (UNITO: University of Turin)H-Index: 24
#2Rizwan Qaisar (UNIPV: University of Pavia)H-Index: 11
Last. Roberto Bottinelli (UNIPV: University of Pavia)H-Index: 53
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Introduction: The aim of this study was to understand the effects of short-term glucocorticoid administration in healthy subjects. Methods: Five healthy men received dexamethasone (8 mg/day) for 7 days. Vastus lateralis muscle biopsy and knee extension torque measurement were performed before and after administration. A large number of individual muscle fibers were dissected from the biopsy samples (pre-administration: n = 165, post-administration: n = 177). Results: Maximal knee extension torqu...
16 CitationsSource
#1Oliver FriedrichH-Index: 34
#2Michael B. ReidH-Index: 59
Last. Lars LarssonH-Index: 48
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Critical illness polyneuropathies (CIP) and myopathies (CIM) are common complications of critical illness. Several weakness syndromes are summarized under the term intensive care unit-acquired weakness (ICUAW). We propose a classification of different ICUAW forms (CIM, CIP, sepsis-induced, steroid-denervation myopathy) and pathophysiological mechanisms from clinical and animal model data. Triggers include sepsis, mechanical ventilation, muscle unloading, steroid treatment, or denervation. Some I...
80 CitationsSource
#1Keita Kanzaki (Kurashiki Sakuyo University)H-Index: 6
#2Mai Kuratani (Hiroshima University)H-Index: 6
Last. Masanobu Wada (Hiroshima University)H-Index: 16
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The present study investigated changes in autolysis of three calpain isoforms in skeletal muscles undergoing eccentric contractions (ECC), leading to prolonged force deficits. Rat extensor digitorum longus and tibialis anterior muscles were exposed to 200-repeated ECC in situ, excised immediately after or 3 or 6 days after cessation of ECC, and used for measures of force output and for biochemical analyses. Full restoration of tetanic force in ECC-treated muscles was not attained until 6 days of...
13 CitationsSource
Cited By2
Newest
#1Takashi Yamada (RMIT: RMIT University)H-Index: 26
#2Yuki Ashida (RMIT: RMIT University)H-Index: 3
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: Patients with cancer cachexia (CCX) suffer from muscle wasting, which is often but not always accompanied by selective loss of myosin. Here we examined the effects of CCX on muscle mass and myosin heavy chain (MyHC) expression in denervated (DEN) muscles, especially focusing on the protein synthesis and degradation pathways. Male CD2F1 mice were randomly divided into control (CNT) and CCX groups and their left sciatic nerve was transected. CCX was induced by an intraperitoneal injection of col...
Source
#1Arthur J. Cheng (UM: University of Michigan)H-Index: 2
#2Baptiste Jude (KI: Karolinska Institutet)H-Index: 1
Last. Johanna T. Lanner (KI: Karolinska Institutet)H-Index: 17
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Abstract Strenuous exercise is a potent stimulus to induce beneficial skeletal muscle adaptations, ranging from increased endurance due to mitochondrial biogenesis and angiogenesis, to increased strength from hypertrophy. While exercise is necessary to trigger and stimulate muscle adaptations, the post-exercise recovery period is equally critical in providing sufficient time for metabolic and structural adaptations to occur within skeletal muscle. These cyclical periods between exhausting exerci...
1 CitationsSource
#1Takashi Yamada (RMIT: RMIT University)H-Index: 26
: In the current issue of Acta Physiologica, Larsson and colleagues examined the effect of chaperone co-inducer BGP-15 on impaired contractile function of the slow-twitch soleus muscles in a rat intensive care unit (ICU) model.1 They found that BGP-15 improves myofibrillar function in the soleus muscle after 5 days exposure to the ICU condition, which is accompanied by improved mitochondrial morphology/biogenesis and reduced oxidative post-translational modifications (PTMs) of myosin molecules.
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#1Takashi Yamada (RMIT: RMIT University)H-Index: 26
#2Yuki Ashida (RMIT: RMIT University)H-Index: 3
Last. Koichi Himori (RMIT: RMIT University)H-Index: 5
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#1Maarten M. Steinz (KI: Karolinska Institutet)H-Index: 2
#2Malin Persson (McGill University)H-Index: 8
Last. Johanna T. Lanner (KI: Karolinska Institutet)H-Index: 17
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Skeletal muscle weakness in patients suffering from rheumatoid arthritis (RA) adds to their impaired working abilities and reduced quality of life. However, little molecular insight is available on ...
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