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Takashi Yamada
Osaka Medical College
ObstetricsEndocrinologyPregnancyDiabetes mellitusMedicine
260Publications
26H-index
2,707Citations
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Publications 251
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#1Tomohito Tanaka (Osaka Medical College)H-Index: 10
#2Shunsuke Miyamoto (Osaka Medical College)H-Index: 1
Last. Takashi Yamada (Osaka Medical College)H-Index: 26
view all 11 authors...
Sentinel node biopsy (SNB) may be a decision-making tool for function preservation surgery, including radical trachelectomy and ovary preservation in the treatment of cervical and endometrial cancer. The intraoperative diagnosis is important for guiding treatment decisions for patients with these conditions. Three hundred seventy-one patients with cervical and endometrial cancer received SNB with an intraoperative frozen section analysis and imprint cytology. The sentinel node was cut in half, p...
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#1Takashi Yamada (RMIT: RMIT University)H-Index: 26
#2Yuki Ashida (RMIT: RMIT University)H-Index: 3
Last. Koichi Himori (RMIT: RMIT University)H-Index: 5
view all 5 authors...
: Patients with cancer cachexia (CCX) suffer from muscle wasting, which is often but not always accompanied by selective loss of myosin. Here we examined the effects of CCX on muscle mass and myosin heavy chain (MyHC) expression in denervated (DEN) muscles, especially focusing on the protein synthesis and degradation pathways. Male CD2F1 mice were randomly divided into control (CNT) and CCX groups and their left sciatic nerve was transected. CCX was induced by an intraperitoneal injection of col...
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#1Mamoru Morikawa (Hokkaido University)H-Index: 22
#2Takashi YamadaH-Index: 26
Last. Hidemichi Watari (Hokkaido University)H-Index: 30
view all 9 authors...
AbstractObjective: To determine whether an antepartum educational leaflet distributed to parents before infant delivery affected the rate of infant car-seat (ICS) use 1 month after delivery, becaus...
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#1Kentaro KaiH-Index: 8
#2Kaei NasuH-Index: 31
Last. Hideki TokunagaH-Index: 12
view all 27 authors...
BACKGROUND: In 2014, the World Health Organization (WHO) released a classification system introducing neuroendocrine neoplasms (NENs) of the female reproductive tract, excluding the ovaries. This study aimed to evaluate whether retrospective adaption of the gastroenteropancreatic (GEP)-NEN classification is feasible for ovarian NENs (O-NENs) and correlates with prognosis. METHODS: Sixty-eight patients diagnosed with carcinoid, small cell carcinoma (pulmonary type), paraganglioma, non-small/large...
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#1Takashi Yamada (RMIT: RMIT University)H-Index: 26
: In the current issue of Acta Physiologica, Larsson and colleagues examined the effect of chaperone co-inducer BGP-15 on impaired contractile function of the slow-twitch soleus muscles in a rat intensive care unit (ICU) model.1 They found that BGP-15 improves myofibrillar function in the soleus muscle after 5 days exposure to the ICU condition, which is accompanied by improved mitochondrial morphology/biogenesis and reduced oxidative post-translational modifications (PTMs) of myosin molecules.
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#1Takashi Yamada (RMIT: RMIT University)H-Index: 26
#2Yuki Ashida (RMIT: RMIT University)H-Index: 3
Last. Koichi Himori (RMIT: RMIT University)H-Index: 5
view all 4 authors...
Although there is good evidence to indicate a major role of intrinsic impairment of the contractile apparatus in muscle weakness seen in several pathophysiological conditions, the factors responsible for control of myofibrillar function are not fully understood. To investigate the role of mechanical load in myofibrillar function, we compared the skinned fiber force between denervated (DEN) and dexamethasone-treated (DEX) rat skeletal muscles with or without neuromuscular electrical stimulation (...
1 CitationsSource
#1Harunobu Matsumoto (Oita University)H-Index: 12
#2Mototsugu ShimokawaH-Index: 15
Last. Norihiro TeramotoH-Index: 18
view all 25 authors...
OBJECTIVE: We conducted a retrospective, multi-institutional, collaborative study to accumulate cases of neuroendocrine carcinoma of the endometrium, to clarify its clinicopathologic features, treatment, prognosis and prognostic factors to collate findings to establish future individualized treatment regimens. To our knowledge, this is the largest case study and the first study to statistically analyze the prognosis of this disease. METHODS: At medical institutions participating in the Kansai Cl...
1 CitationsSource
#1Mamoru Morikawa (Hokkaido University)H-Index: 22
#2Takashi YamadaH-Index: 26
Last. Hidemichi Watari (Hokkaido University)H-Index: 30
view all 9 authors...
Objective To determine whether an educational leaflet had any effect on seat belt use, seat preference and motor vehicle accidents rate during pregnancy in Japan. Design Prospective, non-randomised control trial with a questionnaire survey. Setting Eight obstetric hospitals in Sapporo, Japan. Participants 2216 pregnant women, of whom 1105 received the leaflet (intervention group) and 1111 did not (control group). Interventions Distribution of an educational leaflet on seat belt use to women in t...
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#1Sabine Lotteau (University of Leeds)H-Index: 3
#2Niklas Ivarsson (KI: Karolinska Institutet)H-Index: 11
Last. Sarah Calaghan (University of Leeds)H-Index: 22
view all 13 authors...
Highlights •The authors used human and rat muscle to study the mechanism of statin myopathy and its interaction with exercise. •Statin treatment triggered loss of the modulator protein FKBP from the sarcoplasmic reticulum (SR) calcium (Ca2+) release channel, ryanodine receptor 1 (RyR1). •Loss of FKBP was associated with reactive nitrogen species/reactive oxygen species-dependent SR Ca2+ leak and pro-apoptotic signaling, but had no overt impact on muscle function. •Moderate running wheel exercise...
3 CitationsSource
#1Tomohito Tanaka (Osaka Medical College)H-Index: 10
#2Shunsuke Miyamoto (Osaka Medical College)H-Index: 1
Last. Masahide Ohmichi (Osaka Medical College)H-Index: 25
view all 8 authors...
Purpose: Although laparoscopic radical hysterectomy (LRH) has been performed for patients with cervical cancer because of its minimal invasiveness, a recent large prospective study showed that LRH was associated with a lower rate of disease-free survival and overall survival. However, the reason for these results is not apparent. The aim of this study was to evaluate the tumor spillage during LRH with vaginal closure without the use of a manipulator. Patients and methods: Twenty-four patients wi...
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