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Koichi Himori
RMIT University
EndocrinologyChemistryMuscle weaknessSkeletal muscleMyofibril
13Publications
5H-index
52Citations
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Publications 13
Newest
#1Takashi Yamada (RMIT: RMIT University)H-Index: 26
#2Yuki Ashida (RMIT: RMIT University)H-Index: 3
Last. Koichi Himori (RMIT: RMIT University)H-Index: 5
view all 5 authors...
: Patients with cancer cachexia (CCX) suffer from muscle wasting, which is often but not always accompanied by selective loss of myosin. Here we examined the effects of CCX on muscle mass and myosin heavy chain (MyHC) expression in denervated (DEN) muscles, especially focusing on the protein synthesis and degradation pathways. Male CD2F1 mice were randomly divided into control (CNT) and CCX groups and their left sciatic nerve was transected. CCX was induced by an intraperitoneal injection of col...
Source
#1Takashi Yamada (RMIT: RMIT University)H-Index: 26
#2Yuki Ashida (RMIT: RMIT University)H-Index: 3
Last. Koichi Himori (RMIT: RMIT University)H-Index: 5
view all 4 authors...
Although there is good evidence to indicate a major role of intrinsic impairment of the contractile apparatus in muscle weakness seen in several pathophysiological conditions, the factors responsible for control of myofibrillar function are not fully understood. To investigate the role of mechanical load in myofibrillar function, we compared the skinned fiber force between denervated (DEN) and dexamethasone-treated (DEX) rat skeletal muscles with or without neuromuscular electrical stimulation (...
1 CitationsSource
#1Sabine Lotteau (University of Leeds)H-Index: 3
#2Niklas Ivarsson (KI: Karolinska Institutet)H-Index: 11
Last. Sarah Calaghan (University of Leeds)H-Index: 22
view all 13 authors...
Highlights •The authors used human and rat muscle to study the mechanism of statin myopathy and its interaction with exercise. •Statin treatment triggered loss of the modulator protein FKBP from the sarcoplasmic reticulum (SR) calcium (Ca2+) release channel, ryanodine receptor 1 (RyR1). •Loss of FKBP was associated with reactive nitrogen species/reactive oxygen species-dependent SR Ca2+ leak and pro-apoptotic signaling, but had no overt impact on muscle function. •Moderate running wheel exercise...
3 CitationsSource
#1Koichi Himori (RMIT: RMIT University)H-Index: 5
#2Daisuke Tatebayashi (RMIT: RMIT University)H-Index: 5
Last. Takashi Yamada (RMIT: RMIT University)H-Index: 26
view all 4 authors...
Eccentric contractions (ECCs) are regarded as an effective way to increase muscle strength. No studies, however, assess safety and effectiveness of ECC training on muscle weakness associated with r...
Source
#1Ryotaro Yamada (RMIT: RMIT University)H-Index: 3
#2Koichi Himori (RMIT: RMIT University)H-Index: 5
Last. Takashi Yamada (RMIT: RMIT University)H-Index: 26
view all 10 authors...
KEY POINTS: We examined the mechanisms underlying the positive effect of preconditioning contractions (PCs) on the recovery of muscle force after damaging eccentric contractions (ECCs). The mechanisms underlying the immediate force decrease after damaging ECCs differ from those causing depressed force with a few days' delay, where reactive oxygen species (ROS) produced by invading immune cells play an important causative role. PCs counteracted the delayed onset force depression and this could be...
5 CitationsSource
#1Takashi Yamada (RMIT: RMIT University)H-Index: 26
#2Koichi Himori (RMIT: RMIT University)H-Index: 5
Last. Johanna T. Lanner (KI: Karolinska Institutet)H-Index: 17
view all 13 authors...
Severe muscle weakness concomitant with preferential depletion of myosin has been observed in several pathological conditions. Here we used the steroid-denervation (S-D) rat model, which shows dramatic decrease in myosin content and force production, to test whether electrical stimulation (ES) treatment can prevent these deleterious changes. S-D was induced by cutting the sciatic nerve and subsequent daily injection of dexamethasone for 7 days. For ES treatment, plantarflexor muscles were electr...
2 CitationsSource
#2Koichi HimoriH-Index: 5
Last. Takashi YamadaH-Index: 26
view all 6 authors...
: Eccentric (ECC) contractions are used to maintain skeletal muscle mass and strength in healthy subjects and patients. Here we investigated the effects of ECC training induced by electrical stimulation (ES) on muscle wasting in colon 26 (C-26) tumor-bearing mice. Mice were divided into four groups: control (CNT), CNT + ECC, C-26, and C-26 + ECC. Cancer cachexia was induced by a subcutaneous injection of C-26 cells and developed for four weeks. In experiment 1, muscle protein synthesis rate and ...
Source
#1Yuki Ashida (Sapporo Medical University)H-Index: 3
#2Koichi Himori (Sapporo Medical University)H-Index: 5
Last. Takashi Yamada (Sapporo Medical University)H-Index: 26
view all 6 authors...
Eccentric contraction and high-frequency stimulation (HFS) are regarded as an effective way to increase muscle mass by electrical stimulation (ES) training. However, little is known about whether muscle hypertrophy is affected by contraction mode and stimulation frequency in ES training. Here, we provide the evidence that muscle hypertrophy and mammalian target of rapamycin complex 1 activity are determined by mechanical loading during contraction but not on the contraction mode itself, with a g...
5 CitationsSource
#1Koichi HimoriH-Index: 5
Last. Takashi YamadaH-Index: 26
view all 5 authors...
#1Koichi Himori (RMIT: RMIT University)H-Index: 5
#2Daisuke Tatebayashi (RMIT: RMIT University)H-Index: 5
Last. Takashi Yamada (RMIT: RMIT University)H-Index: 26
view all 7 authors...
Skeletal muscle weakness is a prominent feature in patients with rheumatoid arthritis (RA). In this study, we investigated whether neuromuscular electrical stimulation (NMES) training protects against skeletal muscle dysfunction in rats with adjuvant-induced arthritis (AIA). AIA was produced by intraarticular injection of complete Freund’s adjuvant into the knees of Wistar rats. For NMES training, dorsiflexor muscles were stimulated via a surface electrode (0.5 ms pulse, 50 Hz, 2 s on/4 s off). ...
4 CitationsSource
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