Toward Minimal Residual Disease-Directed Therapy in Melanoma
Abstract
Many patients with advanced cancers achieve dramatic responses to a panoply of therapeutics yet retain minimal residual disease (MRD), which ultimately results in relapse. To gain insights into the biology of MRD, we applied single-cell RNA sequencing to malignant cells isolated from BRAF mutant patient-derived xenograft melanoma cohorts exposed to concurrent RAF/MEK-inhibition. We identified distinct drug-tolerant transcriptional states,...
Paper Details
Title
Toward Minimal Residual Disease-Directed Therapy in Melanoma
Published Date
Aug 1, 2018
Journal
Volume
174
Issue
4
Pages
843 - 855.e19
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Notes
History