Pre-Transplant Assessment of AMR Risk by Novel Donor/Recipient Non-HLA Variants

Background Transplant (tx) injury from antibody mediated (AMR) and T cell mediated (CMR) rejection, limits indefinite survival after HLA mismatched organ tx. AMR is incompletely diagnosed as donor/recipient (D/R) matching is only limited to the HLA locus and critical nHLA immunogenic antigens remain to be identified. Methods We have developed an integrative computational approach leveraging D/R exome sequencing and gene expression to predict...