ABSTRACTIntroduction: The standard of care for monitoring renal transplant patients include transplant biopsy and serum creatinine measurements. These are invasive procedures and are late and nonspecific markers of injury. Proteomics and proteins can provide biomarkers for monitoring pathology and become a useful tool in detection and treatment of conditions that occur after transplant.Areas covered: A survey of 273 studies in the biomarker detection field which included proteomics relating to r...
Abstract This review discusses the current understanding of biomarkers of immune quiescence based on reviews of published literature in kidney transplant operational tolerance and mechanistic studies based on a better characterization of the stable, well-functioning renal allograft.
(University of California, San Francisco), Neil Mercer (University of California, San Francisco), Sharvin Nandoe (University of California, San Francisco)... more
The human microbiome is important for health and plays a role in essential metabolic functions and protection from certain pathogens. Conversely, dysbiosis of the microbiome is seen in the context of various diseases. Recent studies have highlighted that a complex microbial community containing hundreds of bacteria colonizes the healthy urinary tract, but little is known about the human urinary viruses in health and disease. To evaluate the human urinary virome in the context of kidney transplan...
(University of California, San Francisco), Mark Nguyen1
Estimated H-index: 1
(University of California, San Francisco), Dejan Dobi1
Estimated H-index: 1
(University of California, San Francisco)... more
Author(s): Sigdel, TK; Nguyen, M; Dobi, D; Hsieh, S-C; Liberto, JM; Vincenti, F; Sarwal, MM; Laszik, Z | Abstract: Studies are needed to assess the quality of transcriptome analysis in paired human tissue samples preserved by different methods and different gene amplification platforms to enable data comparisons across experimenters.RNA was extracted from kidney biopsies, either submerged in RNA-stabilizing solution (RSS) or stored in formalin-fixed, paraffin-embedded (FFPE) blocks. RNA quality ...