The Relative Immunogenicity of HLA Mismatches in Adult Liver Transplant Patients from the ITN A-WISH Trial

Determining the immunogenicity of HLA mismatches (MM) may help preventing the appearance of de novo DSA (dnDSA) and avoiding antibody-mediated injuries. We studied the development of dnDSA against the HLA-A, -B, -C, -DR and -DQ MM (high resolution) in a cohort of 69 liver transplant patients from the A-WISH trial, which was designed to determine the clinical benefit of early immunosuppression (IS) withdrawal. A total of 764 MM were studied. DQB1...