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Vadim Jucaud
AntibodyHuman leukocyte antigenImmunologyHLA-EMedicine
19Publications
6H-index
87Citations
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Publications 19
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#1Darshana Dadhania (Cornell University)H-Index: 23
#2Cindy H. Park (The Rogosin Institute)H-Index: 1
Last. Manikkam Suthanthiran (The Rogosin Institute)H-Index: 54
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Aim Emerging data suggest that DSA development is a frequent complication post BKV replication, and most DSA are directed against donor HLA-DQ. In the current investigation, we quantified DQ epitope mismatches between the recipient and donor in individuals with BKVN diagnosis and investigated the association between DQ epitope load and development of DSA. Methods In this pilot study, using the most probable 4-digit HLA typings, we investigated epitope mismatches in individuals who developed DSA ...
1 CitationsSource
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#1Vadim JucaudH-Index: 6
#2Abraham ShakedH-Index: 56
Last. Matthew J. EverlyH-Index: 18
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#1Vadim JucaudH-Index: 6
#2Abraham ShakedH-Index: 56
Last. Matthew J. EverlyH-Index: 18
view all 5 authors...
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#2Vadim JucaudH-Index: 6
Last. Soldano Ferrone (Harvard University)H-Index: 91
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Abstract Luminex single antigen bead (SAB) assay utilizes beadsets coated with a set of cloned and purified HLA molecules, for monitoring serum anti-HLA antibodies. Particularly, the level of serum IgG against native HLA-I trimers (heavy chain (HC) and β2-microglobulin (β2 m) with a peptide), expressed in allograft tissues is correlated with graft failure. In addition to native trimeric HLA I, the beadsets may carry HC only or the dimeric variants, peptide-free HC with β2 m and β2 m–free HC with...
5 CitationsSource
#2Vadim JucaudH-Index: 6
Last. Paul I. TerasakiH-Index: 91
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Luminex multiplex immunoassays enable simultaneous monitoring of Abs against multiple Ags in autoimmune, inflammatory, and infectious diseases. The assays are used extensively to monitor anti-HLA Abs in transplant patients for donor organ selection, desensitization, and assessing the risk for graft rejection. To monitor IgG Abs, fluoresceinated IgG constant H chain–binding polyclonal F(ab′) 2 ( IgHPolyFab ) is used as the fluoresceinated secondary Ab (2nd-Ab), whereas IgG subclasses are monitore...
3 CitationsSource
#1Vadim JucaudH-Index: 6
Last. Paul I. TerasakiH-Index: 91
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BackgroundSingle antigen beads (SAB) are used for monitoring HLA antibodies in pretransplant and posttransplant patients despite the discrepancy between virtual and actual crossmatch results and transplant outcomes. This discrepancy can be attributed to the presence of conformational variants of HLA
8 CitationsSource
3 CitationsSource
#1Vadim JucaudH-Index: 6
Last. Robert Biesen (Humboldt University of Berlin)H-Index: 13
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Summary T lymphocyte hyperactivity and progressive inflammation in systemic lupus erythematosus (SLE) patients results in over-expression of human leucocyte antigen (HLA)-Ib on the surface of lymphocytes. These are shed into the circulation upon inflammation, and may augment production of antibodies promoting pathogenicity of the disease. The objective was to evaluate the association of HLA-Ib (HLA-E, HLA-F and HLA-G) antibodies to the disease activity of SLE. The immunoglobulin (Ig)G/IgM reacti...
8 CitationsSource
#2Vadim JucaudH-Index: 6
Last. Paul I. TerasakiH-Index: 91
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Abstract The presence of IgG against pathogens in the cord blood (CB) of vaccinated mothers is attributed to transplacental transfer. However, previous studies using lymphocytotoxicity assay showed anti-HLA IgG in mother’s blood (MB) but not in CB, perhaps due to non-transfer of anti-HLA IgG or assay limitations in detecting anti-HLA IgG. Anti-HLA IgG of native and purified sera of 16 MB and CB pairs were measured using an array of microbeads coated with HLA-I/-II molecules on a Luminex platform...
1 CitationsSource
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