Original paper

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID

Volume: 9, Issue: 1
Published: Jul 24, 2018
Abstract
Base Editor (BE) and Target-AID (activation-induced cytidine deaminase) are engineered genome-editing proteins composed of Cas9 and cytidine deaminases. These base-editing tools convert C:G base pairs to T:A at target sites. Here, we inject either BE or Target-AID mRNA together with identical single-guide RNAs (sgRNAs) into mouse zygotes, and compare the base-editing efficiencies of the two distinct tools in vivo. BE consistently show higher...
Paper Details
Title
Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID
Published Date
Jul 24, 2018
Volume
9
Issue
1
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