Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis
Abstract
ASXL1 mutations occur frequently in myeloid neoplasms and are associated with poor prognosis. However, the mechanisms by which mutant ASXL1 induces leukaemogenesis remain unclear. In this study, we report mutually reinforcing effects between a C-terminally truncated form of mutant ASXL1 (ASXL1-MT) and BAP1 in promoting myeloid leukaemogenesis. BAP1 expression results in increased monoubiquitination of ASXL1-MT, which in turn increases the...
Paper Details
Title
Mutant ASXL1 cooperates with BAP1 to promote myeloid leukaemogenesis
Published Date
Jul 16, 2018
Journal
Volume
9
Issue
1
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