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Effects of an exercise program on hepatic metabolism, hepatic fat, and cardiovascular health in overweight/obese adolescents from Bogotá, Colombia (the HEPAFIT study): study protocol for a randomized controlled trial

Published on Dec 1, 2018in Trials 1.98
· DOI :10.1186/s13063-018-2721-5
Katherine González-Ruíz9
Estimated H-index: 9
(Del Rosario University),
Jorge Enrique Correa Bautista11
Estimated H-index: 11
(Del Rosario University)
+ 12 AuthorsRobinson Ramírez-Vélez19
Estimated H-index: 19
(Del Rosario University)
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Abstract
Background A considerable proportion of contemporary youth have a high risk of obesity-related disorders such as cardiovascular disease, metabolic syndrome, or non-alcoholic fatty liver disease (NAFLD). Although there is consistent evidence for the positive effects of physical activity on several health aspects, most adolescents in Colombia are sedentary. It is, therefore, important to implement strategies that generate changes in lifestyle. The HEPAFIT study aims to examine whether a 6-month exercise program has benefits for hepatic fat content and cardiovascular health outcomes among overweight/obese adolescents from Bogota, Colombia.
  • References (65)
  • Citations (4)
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References65
Newest
Published on Apr 1, 2018in European Journal of Applied Physiology 3.06
Jack A. Sargeant2
Estimated H-index: 2
(Lboro: Loughborough University),
Stephen Bawden3
Estimated H-index: 3
(University of Nottingham)
+ 9 AuthorsPenny A. Gowland53
Estimated H-index: 53
(University of Nottingham)
Purpose This study examined the feasibility of sprint interval exercise training (SIT) for men with non-alcoholic fatty liver disease (NAFLD) and its effects on intrahepatic triglyceride (IHTG), insulin sensitivity (hepatic and peripheral), visceral (VAT) and subcutaneous adipose tissue (ScAT).
Published on Feb 1, 2018in British Journal of Sports Medicine 11.64
Antonio García-Hermoso15
Estimated H-index: 15
(Usach: University of Santiago, Chile),
Robinson Ramírez-Vélez19
Estimated H-index: 19
(Del Rosario University)
+ 2 AuthorsVicente Martínez-Vizcaíno24
Estimated H-index: 24
(UCLM: University of Castilla–La Mancha)
Objective To determine if the combination of aerobic and resistance exercise is superior to aerobic exercise alone for the health of obese children and adolescents. Design Systematic review with meta-analysis. Data sources Computerised search of 3 databases (MEDLINE, EMBASE, and Cochrane Controlled Trials Registry). Eligibility criteria for selecting studies Studies that compared the effect of supervised concurrent exercise versus aerobic exercise interventions, with anthropometric and metabolic...
Published on Dec 1, 2017in Diabetes, Obesity and Metabolism 6.13
Joan Khoo1
Estimated H-index: 1
(CGH: Changi General Hospital),
John Chen Hsiang1
Estimated H-index: 1
(CGH: Changi General Hospital)
+ 2 AuthorsTiing-Leong Ang6
Estimated H-index: 6
(CGH: Changi General Hospital)
We compared the effects of weight loss induced by the glucagon-like peptide 1-agonist liraglutide with a structured lifestyle intervention in obese adults with non-alcoholic fatty liver disease (NAFLD). Obese (body mass index ≥30 kg/m2, mean weight 96.0 ± 16.3 kg) non-diabetic Asian adults, with NAFLD diagnosed by liver fat fraction (LFF) ≥ 5.5% on magnetic resonance imaging without other causes of hepatic steatosis, were randomized to a supervised program of dieting (restriction by 400 kilocalo...
Jorge Cañete García-Prieto8
Estimated H-index: 8
,
Vicente Martínez-Vizcaíno24
Estimated H-index: 24
+ 4 AuthorsRicardo Mora-Rodriguez24
Estimated H-index: 24
The aim of this study was to examine the energy expenditure (EE) measured using indirect calorimetry (IC) during playground games and to assess the validity of heart rate (HR) and accelerometry counts as indirect indicators of EE in children´s physical activity games. 32 primary school children (9.9 ± 0.6 years old, 19.8 ± 4.9 kg · m-2 BMI and 37.6 ± 7.2 ml · kg-1 · min-1 VO2max). Indirect calorimetry (IC), accelerometry and HR data were simultaneously collected for each child during a 90 min se...
Published on Sep 1, 2017
Emily R. Perito12
Estimated H-index: 12
(UCSF: University of California, San Francisco),
Veeral Ajmera8
Estimated H-index: 8
(UCSF: University of California, San Francisco)
+ 11 AuthorsKaren F. Murray33
Estimated H-index: 33
Reliable noninvasive markers to characterize inflammation, hepatocellular ballooning, and fibrosis in nonalcoholic fatty liver disease (NAFLD) are lacking. We investigated the relationship between plasma cytokine levels and features of NAFLD histology to gain insight into cellular pathways driving nonalcoholic steatohepatitis (NASH) and to identify potential noninvasive discriminators of NAFLD severity and pattern. Cytokines were measured from plasma obtained at enrollment in pediatric participa...
Published on Aug 1, 2017in Childhood obesity 2.43
Katherine González-Ruíz9
Estimated H-index: 9
(Del Rosario University),
Robinson Ramírez-Vélez19
Estimated H-index: 19
(Del Rosario University)
+ 2 AuthorsAntonio García-Hermoso15
Estimated H-index: 15
(Usach: University of Santiago, Chile)
Abstract Background: Despite the prevalence of obesity and the multiple position stands promoting exercise for the treatment of obesity and hepatic function, a meta-analytic approach has not previously been used to examine the effects in the pediatric population. The aim of the study was to determine the effectiveness of exercise interventions on abdominal fat, liver enzymes, and intrahepatic fat in overweight and obese youth. Materials and Methods: A computerized search was made using three dat...
Published on Aug 1, 2017in Journal of Strength and Conditioning Research 3.02
Robinson Ramírez-Vélez19
Estimated H-index: 19
,
Martin Martínez1
Estimated H-index: 1
+ 4 AuthorsCarlos Cristi-Montero7
Estimated H-index: 7
The purpose of the present study was to generate normative values for standing long jump test (SLJ) in 9- to 17.9-year-olds and to investigate sex and age group differences. The sample was comprised of 8,034 healthy Colombian schoolchildren [boys n=3,488 and girls n=4,546; mean (standard deviation) age 12.8 (±2.3) years old]. Each participant performed two SLJ. Centile smoothed curves, percentile, and tables for the 3rd, 10th, 25th, 50th, 75th, 90th, and 97th percentiles were calculated using Co...
Published on Jun 1, 2017in Journal of Science and Medicine in Sport 3.62
Eero A. Haapala9
Estimated H-index: 9
(University of Jyväskylä),
Juuso Väistö7
Estimated H-index: 7
(University of Eastern Finland)
+ 5 AuthorsTimo A. Lakka78
Estimated H-index: 78
(University of Eastern Finland)
Abstract Objectives To investigate the independent and combined associations of objectively measured moderate-to-vigorous physical activity (MVPA) and sedentary time (ST) with reading and arithmetic skills. Design Cross-sectional/prospective. Methods Participants were 89 boys and 69 girls aged 6–8 years. MVPA and ST were measured using a combined heart rate and movement sensor and body fat percentage by dual-energy X-ray absorptiometry in Grade 1. Reading fluency, reading comprehension, and arit...
Ala Ustyol1
Estimated H-index: 1
,
Esra Aycan Üstyol1
Estimated H-index: 1
(Istanbul University)
+ 2 AuthorsSeldag Bekpinar6
Estimated H-index: 6
(Istanbul University)
AbstractThere is increasing evidence for a direct relationship between the vascular system and non-alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate endocan and adhesion molecules such as P-selectin derived from the endothelium and platelets in obese children and adolescents with NAFLD. One hundred obese patients and 40 lean controls were enrolled. The obese subjects were divided into two subgroups based on the presence or absence of fatty liver. Blood samples were ...
Published on Apr 1, 2017in Journal of Science and Medicine in Sport 3.62
Cristina Cadenas-Sanchez12
Estimated H-index: 12
(UGR: University of Granada),
Jérémy Vanhelst14
Estimated H-index: 14
(French Institute of Health and Medical Research)
+ 12 AuthorsAndrés Catena28
Estimated H-index: 28
(UGR: University of Granada)
Abstract Objectives To examine the association of health-related physical fitness components and accurate measures of fatness with attention in European adolescents. Design Cross-sectional study. Methods A sub-sample of 444 adolescents from the HELENA study (14.5±1.2years) from 6 different countries participated in this study. Adolescents underwent evaluations of fitness (20m shuttle run, handgrip strength, standing long jump and 4×10m shuttle run tests), fatness (body mass index, skinfold thick...
Cited By4
Newest
Published on Apr 1, 2019in Molecular and Cellular Biochemistry 2.88
Biljana Jakovljevic1
Estimated H-index: 1
,
Tamara Nikolic Turnic1
Estimated H-index: 1
(University of Kragujevac)
+ 8 AuthorsOlga Pechanova29
Estimated H-index: 29
This study was aimed to assess the impact of aerobic and anaerobic type of exercise on blood pressure and redox status in normotensive and hypertensive rats. After 1 week of preconditioning feeding and 1 week of preconditioning running regimen, Wistar albino rats (n = 72; bw: 270 ± 50 g) were randomly assigned to three groups according to running protocol (high-intensity interval training (HIIT) or moderate-intensity training (MIT)): sedentary control, MIT, HIIT; spontaneous hypertensive sedenta...
Published on Dec 7, 2018in Journal of Clinical Medicine
Robinson Ramírez-Vélez19
Estimated H-index: 19
,
Mikel Izquierdo51
Estimated H-index: 51
+ 4 AuthorsKatherine González-Jiménez
This study had two main objectives: To examine the association between body fat distribution and non-alcoholic fatty liver disease (NAFLD) and liver fat content, and to determine whether the relationship between NAFLD and regional body fat distribution, with respect to liver fat content in youths with excess adiposity, is independent of cardiorespiratory fitness (CRF) and a healthy diet. Liver fat content (controlled attenuation parameter (CAP)), body fat distribution (body mass index (BMI) z-sc...
Published on Oct 12, 2018in Journal of Clinical Medicine
Robinson Ramírez-Vélez19
Estimated H-index: 19
,
Mikel Izquierdo51
Estimated H-index: 51
+ 5 AuthorsKatherine González-Ruíz9
Estimated H-index: 9
Paediatric non-alcoholic fatty liver disease (NAFLD) is considered the most common early driver of chronic liver disease. The aim of this study was to examine whether grip strength moderates the association between anthropometric and body composition parameters and controlled attenuation parameter (CAP), an indicator of fat deposits in the liver, in children and adolescents with excess of adiposity. A total of 127 adolescents (67% girls) aged between 11 and 17, attending two public schools in Bo...
Published on Aug 14, 2018in Nutrients 4.17
Katherine González-Ruíz9
Estimated H-index: 9
,
María Medrano4
Estimated H-index: 4
+ 8 AuthorsEmilio González Jiménez12
Estimated H-index: 12
(UGR: University of Granada)
Dual-energy X-ray absorptiometry (DXA) has been considered a reference method for measuring body fat percentage (BF%) in children and adolescents with an excess of adiposity. However, given that the DXA technique is impractical for routine field use, there is a need to investigate other methods that can accurately determine BF%. We studied the accuracy of bioelectrical impedance analysis (BIA) technology, including foot-to-foot and hand-to-foot impedance, and Slaughter skinfold-thickness equatio...