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Published on Feb 12, 2019in Trials1.98
Christopher Price19
Estimated H-index: 19
(Newcastle University),
Lisa Shaw7
Estimated H-index: 7
(Newcastle University)
+ 16 AuthorsJoanne Lally9
Estimated H-index: 9
(Newcastle University)
Despite evidence from clinical trials that intravenous (IV) thrombolysis is a cost-effective treatment for selected acute ischaemic stroke patients, there remain large variations in the rate of IV thrombolysis delivery between stroke services. This study is evaluating whether an enhanced care pathway delivered by paramedics (the Paramedic Acute Stroke Treatment Assessment (PASTA)) could increase the number of patients who receive IV thrombolysis treatment. Study design: Cluster randomised trial ...
Published on Jan 29, 2019in Trials1.98
Fabienne Marlats1
Estimated H-index: 1
(Paris V: Paris Descartes University),
Leila Djabelkhir-Jemmi (Paris V: Paris Descartes University)+ 3 AuthorsAnne-Sophie Rigaud30
Estimated H-index: 30
(Paris V: Paris Descartes University)
Background Older adults with Mild Cognitive Impairment (MCI) are at high risk of progressing to Alzheimer’s disease (AD). Slowing down the effect of dementia by enhancing brain plasticity represents one of the most prominent challenges. Neurofeedback (NF) has shown promising results in improving working memory but has never been evaluated in people with MCI. We aim to examine whether NF training can decrease cognitive disorders, targeting memory, attention functions and brain electrical activity...
Published on Jan 17, 2019in Trials1.98
Zhiwei Wu (SHU: Shanghai University), Lingjun Kong + 9 AuthorsGuangxin Guo (SHU: Shanghai University)
Background Chronic neck pain (CNP) is a common and disabling musculoskeletal disorder in developing and developed countries. Previous studies have shown that tuina and traditional Chinese massage are effective treatments for patients with CNP. However, there is little evidence to support the use of one intervention over the other. The aim of this study is to compare the effects of tuina and traditional Chinese massage in the treatment of pain and disability in patients with CNP.
Published on Dec 1, 2019in Trials1.98
Bergthor Björnsson11
Estimated H-index: 11
(Linköping University),
Per Sandström20
Estimated H-index: 20
(Linköping University)
+ 2 AuthorsThomas Gasslander12
Estimated H-index: 12
(Linköping University)
Background Earlier nonrandomized studies have suggested that laparoscopic distal pancreatectomy (LDP) is advantageous compared with open distal pancreatectomy (ODP) regarding hospital stay, blood loss, and recovery. Only one randomized study has been conducted showing reduced time to functional recovery after LDP compared with ODP.
Published in Trials1.98
Yiqi Pan1
Estimated H-index: 1
(UHH: University of Hamburg),
Ramona Meister5
Estimated H-index: 5
(UHH: University of Hamburg)
+ -3 AuthorsYvonne Nestoriuc18
Estimated H-index: 18
(UHH: University of Hamburg)
Beneficial effects of placebos are high in double-blind hot flush trials. Studies in various conditions suggest that honestly prescribed placebos may elicit symptom improvement. To determine whether open label placebo (OLP) treatment is efficacious in alleviating hot flushes among peri- and postmenopausal women. In this assessor-blinded, randomized-controlled trial, n = 100 women experiencing five or more daily hot flushes of at least moderate severity and bothersomeness are assigned 1:1 to a 4-...
Published on Jan 31, 2019in Trials1.98
Qiuxia Cui1
Estimated H-index: 1
(WHU: Wuhan University),
Deguang Kong1
Estimated H-index: 1
(WHU: Wuhan University)
+ 7 AuthorsGaosong Wu1
Estimated H-index: 1
(WHU: Wuhan University)
Hypoparathyroidism is one of the most common complications encountered in thyroidectomy. In addition to parathyroid in-situ preservation, parathyroid autotransplantation (PA) is another important remedial method for patients whose parathyroid glands have been removed. However, an accurate evaluation method for the function of a transplanted parathyroid is lacking. Our preliminary study indicated that patients with PA at novel sites near antecubital veins had higher serum concentrations of parath...
Published on Dec 1, 2019in Trials1.98
Yulin Li (SHU: Shanghai University), Lixi Chu1
Estimated H-index: 1
(SHU: Shanghai University)
+ 12 AuthorsJing Zhang
Background Total knee arthroplasty (TKA) is an optimal option for patients with middle-to-end-stage knee osteoarthritis. However, the management of postoperative acute pain remains inefficient. Transcutaneous electrical acupoint stimulation (TEAS) is a nonpharmacological method to manage postoperative acute pain. Different frequencies of TEAS have been tested using varying parameters, but the optimal analgesic frequency remains controversial. The aim of this study was to explore the optimal anal...
Published on Dec 1, 2019in Trials1.98
Johannes S. Kern (University of Freiburg), Agnes Schwieger-Briel7
Estimated H-index: 7
+ 3 AuthorsAnna E. Martinez16
Estimated H-index: 16
(GOSH: Great Ormond Street Hospital)
Background Epidermolysis bullosa (EB) is a group of rare, genetic diseases that affect the integrity of epithelial tissues, most notably the skin. Patients experience recurrent skin wounding, with severity depending on type, sub-type, and mutation. Oleogel-S10, a formulation of birch bark extract, has demonstrated efficacy in a Phase 2 trial assessing re-epithelialization of wounds in EB. EASE (NCT03068780, EudraCT 2016–002066-32) is a randomized, Phase 3, placebo-controlled study designed to de...
Published on Dec 1, 2019in Trials1.98
Hyo-Weon Suh3
Estimated H-index: 3
(Kyung Hee University),
Jinsung Kim26
Estimated H-index: 26
+ 7 AuthorsJun-Hwan Lee6
Estimated H-index: 6
Mild cognitive impairment (MCI) is defined as a decline in cognitive state with preservation of activities of daily living. Medications such as donepezil and rivastigmine have been commonly prescribed for MCI, but their use is controversial. Acupuncture has been widely used in Korea and has been shown to improve cognitive function. The aim of this study is to evaluate the efficacy of acupuncture for MCI and investigate the effect of acupuncture on structural and functional brain changes in patie...
Published on Apr 2, 2019in Trials1.98
T. M. Wassenaar (John Radcliffe Hospital), C. M. Wheatley (John Radcliffe Hospital)+ 7 AuthorsHeidi Johansen-Berg80
Estimated H-index: 80
(John Radcliffe Hospital)
Background Early adolescence is a period of dynamic neurobiological change. Converging lines of research suggest that regular physical activity (PA) and improved aerobic fitness have the potential to stimulate positive brain changes, improve cognitive function and boost academic attainment in this age group, but high-quality studies are needed to substantiate these findings. The primary aim of the Fit to Study trial is to investigate whether short infusions of vigorous PA (VPA) delivered during ...
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