Original paper

CaMKII-dependent late Na+current increases electrical dispersion and arrhythmia in ischemia-reperfusion

Volume: 315, Issue: 4, Pages: H794 - H801
Published: Oct 1, 2018
Abstract
The mechanisms underlying Ca 2+ /calmodulin-dependent protein kinase II (CaMKII)-induced arrhythmias in ischemia-reperfusion (I/R) are not fully understood. We tested the hypothesis that CaMKII increases late Na + current ( I Na,L ) via phosphorylation of Na v 1.5 at Ser 571 during I/R, thereby increasing arrhythmia susceptibility. To test our hypothesis, we studied isolated, Langendorff-perfused hearts from wild-type (WT) mice and mice...
Paper Details
Title
CaMKII-dependent late Na+current increases electrical dispersion and arrhythmia in ischemia-reperfusion
Published Date
Oct 1, 2018
Volume
315
Issue
4
Pages
H794 - H801
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