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American Journal of Physiology-heart and Circulatory Physiology
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#1Si Lei (CSU: Central South University)
#2Fei Peng (CSU: Central South University)
Last. Shang-Jie Wu (CSU: Central South University)
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BACKGROUND Pulmonary arterial hypertension (PAH) is a fatal progressive disease characterized by an increased blood pressure in the pulmonary arteries. RhoA/Rho-kinase (RhoA/ROCK) signaling activation is often associated with PAH. The purpose of this study is to investigate the role and mechanisms of long non-coding RNA (lncRNA) Smooth muscle-induced lncRNA (SMILR) to activate RhoA/ROCK pathway in PAH. METHODS SMILR, microRNA-141 (miR-141) and RhoA were identified by qRT-PCR in PAH patients' ser...
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#1Amina Kunovac (WVU: West Virginia University)H-Index: 2
#2Quincy A. Hathaway (WVU: West Virginia University)H-Index: 5
Last. John M. Hollander (WVU: West Virginia University)H-Index: 28
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Ambient air, occupational settings, and the use and distribution of consumer products all serve as conduits for toxicant exposure through inhalation. While the pulmonary system remains a primary target following inhalation exposure, cardiovascular implications are exceptionally culpable for increased morbidity and mortality. The epidemiological evidence for cardiovascular dysfunction resulting from acute or chronic inhalation exposure to particulate matter has been well documented, but the mecha...
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#1Brett J. Wong (GSU: Georgia State University)H-Index: 20
#2Casey G. Turner (GSU: Georgia State University)
Last. Arshed A. Quyyumi (Emory University)H-Index: 59
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The purpose of this study was to investigate the effect of race and subclinical elevations in blood pressure (i.e., prehypertension) on cutaneous sensory nerve-mediated and NO-dependent vasodilation. We recruited participants who self-identified as either non-Hispanic Black (n=16) or non-Hispanic White (n=16). Within each group, participants were subdivided as either normotensive (n=8 per group) or prehypertensive (n=8 per group). Each participant was instrumented with four intradermal microdial...
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#1Sara Arastoo (UCLA: University of California, Los Angeles)H-Index: 1
#2Kacey P Haptonstall (UCLA: University of California, Los Angeles)
Last. Holly R. Middlekauff (UCLA: University of California, Los Angeles)H-Index: 43
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Electronic cigarettes(ECs) and tobacco cigarettes(TCs) both release nicotine, a sympathomimetic drug. We hypothesized that baseline heart rate variability(HRV) and hemodynamics would be similar in chronic EC and TC-smokers, and that after acute EC use, changes in HRV and hemodynamics would be attributable to nicotine, not non-nicotine constituents in EC aerosol. In 100 smokers, including 58 chronic EC-users and 42 TC-smokers, baseline HRV and hemodynamics (blood pressure[BP] and heart rate[HR]) ...
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#1Luca Toth (PTE: University of Pécs)
#2András Czigler (PTE: University of Pécs)H-Index: 1
Last. Peter Toth (PTE: University of Pécs)H-Index: 25
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#1Yu Patrick Shi (SFU: Simon Fraser University)H-Index: 2
#2ZhaoKai Pang (SFU: Simon Fraser University)
Last. Shoaib Faizi (SFU: Simon Fraser University)
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hERG K+ channels are important in cardiac repolarization and their dysfunction causes prolongation of the ventricular action potential, Long QT Syndrome, and arrhythmia. As such, approaches to augment hERG channel function, such as activator compounds, have been of significant interest due to their marked therapeutic potential. Activator compounds that hinder channel inactivation abbreviate action potential duration (APD), but carry risk of over-correction leading to Short QT Syndrome. Enhanced ...
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#1Andrew V. Kuczmarski (UD: University of Delaware)H-Index: 1
#2Leena N. Shoemaker (UD: University of Delaware)
Last. Megan M. Wenner (UD: University of Delaware)H-Index: 11
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The endothelin system plays an important role in mediating vascular function. The endothelin-B receptor (ETBR) on endothelial cells mediates vasodilation via nitric oxide production. The vasodilatory effect of the ETBR is lost following menopause and may contribute to impaired vascular endothelial function in postmenopausal women (PMW). However, it is unclear if these functional changes are due to changes in ETBR expression on the endothelium. Therefore, the purpose of this study was to test the...
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#1Denis Babici (RU: Rutgers University)H-Index: 1
#2Raymond K. Kudej (Tufts University)H-Index: 25
Last. Stephen F. Vatner (RU: Rutgers University)H-Index: 30
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OBJECTIVE Protection against increased vascular stiffness in young women is lost after menopause. However, little is known about vascular stiffness in older, pre-menopausal females, because most of the prior work has been conducted in rodents, which live for only 1-3 years and do not go through menopause. The goal of the current investigation was to quantitate differences in stiffness down the aortic tree, and the mechanisms mediating those differences, in older, pre-menopausal (24 ± 0.7 years) ...
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#1Korynne S. Rollins (KSU: Kansas State University)H-Index: 3
#2Alec L. Butenas (KSU: Kansas State University)H-Index: 2
Last. Steven W. Copp (KSU: Kansas State University)H-Index: 20
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The exercise pressor reflex is a feedback autonomic and cardiovascular control mechanism evoked by mechanical and metabolic signals within contracting skeletal muscles. The mechanically sensitive component of the reflex (the mechanoreflex) is exaggerated in peripheral artery disease (PAD) patients and in a rat model of simulated PAD in which a femoral artery is chronically ligated. Products of cyclooxygenase enzyme activity have been shown to chronically sensitize the mechanoreflex in PAD but th...
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Top fields of study
Endocrinology
Biochemistry
Medicine
Circulatory system
Biology