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Liquid Sucrose Consumption Promotes Obesity and Impairs Glucose Tolerance Without Altering Circulating Insulin Levels

Published on Jul 1, 2018in Obesity3.969
路 DOI :10.1002/oby.22217
Susan J. Burke14
Estimated H-index: 14
,
Heidi M. Batdorf3
Estimated H-index: 3
+ 6 AuthorsJ. Jason Collier18
Estimated H-index: 18
Abstract
  • References (45)
  • Citations (1)
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References45
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#1Kyoung Han Kim (U of O: University of Ottawa)H-Index: 4
#2Yun Hye KimH-Index: 2
Last. Hoon Ki Sung (U of T: University of Toronto)H-Index: 19
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Intermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage
23 CitationsSource
This study aims to analyse the non-linear relationship between Body Mass Index (BMI) and direct health care costs, and to quantify the resulting cost fraction attributable to obesity in Germany. Five cross-sectional surveys of cohort studies in southern Germany were pooled, resulting in data of 6757 individuals (31鈥96 years old). Self-reported information on health care utilisation was used to estimate direct health care costs for the year 2011. The relationship between measured BMI and annual c...
4 CitationsSource
#1Susan J. Burke (Pennington Biomedical Research Center)H-Index: 14
#2Heidi M. Batdorf (Pennington Biomedical Research Center)H-Index: 3
Last. J. Jason Collier (Pennington Biomedical Research Center)H-Index: 18
view all 8 authors...
Steroid-induced diabetes is the most common form of drug-induced hyperglycemia. Therefore, metabolic and immunological alterations associated with chronic oral corticosterone were investigated using male nonobese diabetic mice. Three weeks after corticosterone delivery, there was reduced sensitivity to insulin action measured by insulin tolerance test. Body composition measurements revealed increased fat mass and decreased lean mass. Overt hyperglycemia (>250 mg/dL) manifested 6 weeks after the ...
10 CitationsSource
#1Susan J. Burke (Pennington Biomedical Research Center)H-Index: 14
#2Heidi M. Batdorf (Pennington Biomedical Research Center)H-Index: 3
Last. J. Jason Collier (Pennington Biomedical Research Center)H-Index: 18
view all 8 authors...
To understand features of human obesity and type 2 diabetes mellitus (T2D) that can be recapitulated in the mouse, we compared C57BL/6J mice fed a Western-style diet (WD) to weight-matched genetically obese leptin receptor-deficient mice (db/db). All mice were monitored for changes in body composition, glycemia, and total body mass. To objectively compare diet-induced and genetic models of obesity, tissue analyses were conducted using mice with similar body mass. We found that adipose tissue inf...
12 CitationsSource
#1Susan J. Burke (Pennington Biomedical Research Center)H-Index: 14
#2Michael D. Karlstad (UTHSC: University of Tennessee Health Science Center)H-Index: 19
Last. J. Jason Collier (Pennington Biomedical Research Center)H-Index: 18
view all 7 authors...
Type 1 diabetes mellitus (T1DM) results from immune cell-mediated reductions in function and mass of the insulin-producing 尾-cells within the pancreatic islets. While the initial trigger(s) that initiates the autoimmune process is unknown, there is a leukocytic infiltration that precedes islet 尾-cell death and dysfunction. Herein, we demonstrate that genes encoding the chemokines CXCL9, 10, and 11 are primary response genes in pancreatic 尾-cells and are also elevated as part of the inflammatory ...
10 CitationsSource
#1James M. Rippe (Emory and Henry College)H-Index: 4
Added sugars are a controversial and hotly debated topic. Consumption of added sugars has been implicated in increased risk of a variety of chronic diseases including obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (NAFLD) as well as cognitive decline and even some cancers. Support for these putative associations has been challenged, however, on a variety of fronts. The purpose of the current review is to summarize high impact evidence including systematic reviews...
22 CitationsSource
#1Anna M. D'souza (UBC: University of British Columbia)H-Index: 4
#2James D. Johnson (UBC: University of British Columbia)H-Index: 40
Last. Timothy J. Kieffer (UBC: University of British Columbia)H-Index: 52
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Abstract Objective Hyperinsulinemia is commonly associated with obesity. Mice deficient in the adipose-derived hormone leptin ( Lep ob/ob ) develop hyperinsulinemia prior to onset of obesity and glucose intolerance. Whether the excess of circulating insulin is a major contributor to obesity and impaired glucose homeostasis in Lep ob/ob mice is unclear. It has been reported previously that diet-induced obesity in mice can be prevented by reducing insulin gene dosage. In the present study, we exam...
16 CitationsSource
#1Thomas Laeger (Pennington Biomedical Research Center)H-Index: 12
#2Diana C. Albarado (Pennington Biomedical Research Center)H-Index: 9
Last. Christopher D. Morrison (Pennington Biomedical Research Center)H-Index: 33
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Summary FGF21 contributes to the metabolic response to dietary protein restriction, and prior data implicate GCN2 as the amino acid sensor linking protein restriction to FGF21 induction. Here, we demonstrate the persistent and essential role of FGF21 in the metabolic response to protein restriction. We show that Fgf21 KO mice are fully resistant to low protein (LP)-induced changes in food intake, energy expenditure (EE), body weight gain, and metabolic gene expression for 6聽months. Gcn2 KO mice ...
59 CitationsSource
AbstractThe impact of sugar consumption on health continues to be a controversial topic. The objective of this review is to discuss the evidence and lack of evidence that allows the controversy to continue, and why resolution of the controversy is important. There are plausible mechanisms and research evidence that supports the suggestion that consumption of excess sugar promotes the development of cardiovascular disease (CVD) and type 2 diabetes (T2DM) both directly and indirectly. The direct p...
143 CitationsSource
#1Mariachiara Di Cesare (Imperial College London)H-Index: 17
#2James Bentham (Imperial College London)H-Index: 13
Last. Julio Zuniga CisnerosH-Index: 8
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Background Underweight and severe and morbid obesity are associated with highly elevated risks of adverse health outcomes. We estimated trends in mean body-mass index (BMI), which characterises its population distribution, and in the prevalences of a complete set of BMI categories for adults in all countries. Methods We analysed, with use of a consistent protocol, population-based studies that had measured height and weight in adults aged 18 years and older. We applied a Bayesian hierarchical mo...
1,312 CitationsSource
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#1Raffaella SoletiH-Index: 12
Last. Emmanuel GeoffriauH-Index: 7
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Carrots鈥 genotype and growing conditions influence their potential properties to fight against cardiovascular and metabolic diseases. The present study evaluated the influence of carrot genotypes contrasted by root color (Bolero, Presto, Karotan, Deep Purple, Kintoki and Blanche des Vosges) growing under standard, water-restricted, biotic stress (Alternaria dauci inoculation), and combined stress conditions (water restriction and A.dauci inoculation). The effect of carrots鈥 polyphenol and carote...
Source
#1J. Jason Collier (Pennington Biomedical Research Center)H-Index: 18
#2Heidi M. Batdorf (Pennington Biomedical Research Center)H-Index: 3
Last. Susan J. Burke (Pennington Biomedical Research Center)H-Index: 14
view all 8 authors...
There are endocrine and immunological changes that occur during onset and progression of the overweight and obese states. The inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKe) was o...
Source
#1Susan J. Burke (Pennington Biomedical Research Center)H-Index: 14
#2Heidi M. Batdorf (Pennington Biomedical Research Center)H-Index: 3
Last. J. Jason Collier (Pennington Biomedical Research Center)
view all 14 authors...
Abstract Clinical glucocorticoid use, and diseases that produce elevated circulating glucocorticoids, promote drastic changes in body composition and reduction in whole body insulin sensitivity. Because steroid-induced diabetes is the most common form of drug-induced hyperglycemia, we investigated mechanisms underlying the recognized phenotypes associated with glucocorticoid excess. Male C57BL/6鈥塉 mice were exposed to either 100ug/mL corticosterone (cort) or vehicle in their drinking water. Body...
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