Original paper
Cattle with a precise, zygote-mediated deletion safely eliminate the major milk allergen beta-lactoglobulin
Abstract
We applied precise zygote-mediated genome editing to eliminate beta-lactoglobulin (BLG), a major allergen in cows' milk. To efficiently generate LGB knockout cows, biopsied embryos were screened to transfer only appropriately modified embryos. Transfer of 13 pre-selected embryos into surrogate cows resulted in the birth of three calves, one dying shortly after birth. Deep sequencing results confirmed conversion of the genotype from wild type to...
Paper Details
Title
Cattle with a precise, zygote-mediated deletion safely eliminate the major milk allergen beta-lactoglobulin
Published Date
May 16, 2018
Journal
Volume
8
Issue
1
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Notes
History