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Analysis of type 2 diabetes and obesity genetic variants in Mexican Pima Indians: Marked allelic differentiation among Amerindians at HLA

Published on Sep 1, 2018in Annals of Human Genetics1.319
· DOI :10.1111/ahg.12252
Wen-Chi Hsueh29
Estimated H-index: 29
(NIH: National Institutes of Health),
Peter H. Bennett89
Estimated H-index: 89
(NIH: National Institutes of Health)
+ 8 AuthorsRobert L. Hanson72
Estimated H-index: 72
(NIH: National Institutes of Health)
Abstract
  • References (59)
  • Citations (1)
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References59
Newest
#1Diogo Meyer (USP: University of São Paulo)H-Index: 24
#2Vitor R. C. Aguiar (USP: University of São Paulo)H-Index: 6
Last. Kelly Nunes (USP: University of São Paulo)H-Index: 7
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Several decades of research have convincingly shown that classical human leukocyte antigen (HLA) loci bear signatures of natural selection. Despite this conclusion, many questions remain regarding the type of selective regime acting on these loci, the time frame at which selection acts, and the functional connections between genetic variability and natural selection. In this review, we argue that genomic datasets, in particular those generated by next-generation sequencing (NGS) at the populatio...
31 CitationsSource
#1Wen-Chi Hsueh (NIH: National Institutes of Health)H-Index: 29
#2Anup K. Nair (NIH: National Institutes of Health)H-Index: 4
Last. Robert L. Hanson (NIH: National Institutes of Health)H-Index: 72
view all 10 authors...
Background— Identity-by-descent mapping using empirical estimates of identity-by-descent allele sharing may be useful for studies of complex traits in founder populations, where hidden relationships may augment the inherent genetic information that can be used for localization. Methods and Results— Through identity-by-descent mapping, using ≈400 000 single-nucleotide polymorphisms (SNPs), of serum lipid profiles, we identified a major linkage signal for triglycerides in 1007 Pima Indians (LOD=9....
5 CitationsSource
#1Gonneke Willemsen (VU: VU University Amsterdam)H-Index: 88
#2Kirsten Ward ('KCL': King's College London)H-Index: 14
Last. Tim D. Spector ('KCL': King's College London)H-Index: 165
view all 18 authors...
Twin pairs discordant for disease may help elucidate the epigenetic mechanisms and causal environmental factors in disease development and progression. To obtain the numbers of pairs, especially monozygotic (MZ) twin pairs, necessary for in-depth studies while also allowing for replication, twin studies worldwide need to pool their resources. The Discordant Twin (DISCOTWIN) consortium was established for this goal. Here, we describe the DISCOTWIN Consortium and present an analysis of type 2 diab...
38 CitationsSource
#1Gonneke WillemsenH-Index: 88
#2Kirsten WardH-Index: 14
Last. Tim D. SpectorH-Index: 165
view all 18 authors...
Twin pairs discordant for disease may help elucidate the epigenetic mechanisms and causal environmental factors in disease development and progression. To obtain the numbers of pairs, especially monozygotic (MZ) twin pairs, necessary for in-depth studies while also allowing for replication, twin studies worldwide need to pool their resources. The Discordant Twin (DISCOTWIN) consortium was established for this goal. Here, we describe the DISCOTWIN Consortium and present an analysis of type 2 diab...
34 CitationsSource
#2Mauro E. ValenciaH-Index: 22
Last. Leslie O. Schulz (NAU: Northern Arizona University)H-Index: 17
view all 9 authors...
OBJECTIVE The global epidemics of type 2 diabetes and obesity have been attributed to the interaction between lifestyle changes and genetic predisposition to these diseases. We compared the prevalences of type 2 diabetes and obesity in Mexican Pima Indians, presumed to have a high genetic predisposition to these diseases, to those in their non-Pima neighbors, both of whom over a 15-year period experienced transition from a traditional to a more modern lifestyle. RESEARCH DESIGN AND METHODS Preva...
16 CitationsSource
#1Xinli HuH-Index: 13
#2Aaron J. DeutschH-Index: 6
Last. Soumya RaychaudhuriH-Index: 74
view all 11 authors...
Soumya Raychaudhuri and colleagues present a detailed analysis of the association between the HLA region and type 1 diabetes risk. They find that variants at three amino acid positions in HLA-DQβ1 and HLA-DRβ1 account for a large fraction of the association signal, acting through a combination of additive and interaction effects.
91 CitationsSource
#1Robert L. Hanson (NIH: National Institutes of Health)H-Index: 9
#2Rong Rong (NIH: National Institutes of Health)H-Index: 2
Last. Leslie J. Baier (NIH: National Institutes of Health)H-Index: 36
view all 8 authors...
Several single nucleotide polymorphisms (SNPs) associated with type 2 diabetes mellitus (T2DM) have been identified, but there is little information on their role in populations at high risk for T2DM. We genotyped SNPs at 63 T2DM loci in 3,421 individuals from a high-risk American Indian population. Nominally significant ( P P = 6.2 × 10 −6 ) and, in 292 nondiabetic individuals, with lower insulin secretion (by 4% per copy, P = 4.1 × 10 −6 ). Genetic distances between American Indians and HapMap...
15 CitationsSource
#1Adam E. Locke (UM: University of Michigan)H-Index: 25
#2Bratati Kahali (UM: University of Michigan)H-Index: 14
Last. Elizabeth K. Speliotes (UM: University of Michigan)H-Index: 27
view all 482 authors...
Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new...
1,783 CitationsSource
#1Zachary A. Szpiech (UCSF: University of California, San Francisco)H-Index: 13
#2Ryan D. Hernandez (UCSF: University of California, San Francisco)H-Index: 32
Haplotype-based scans to detect natural selection are useful to identify recent or ongoing positive selection in genomes. As both real and simulated genomic data sets grow larger, spanning thousands of samples and millions of markers, there is a need for a fast and efficient implementation of these scans for general use. Here, we present selscan ,a n eff icient multithreaded application that implements Extended Haplotype Homozygosity (EHH), Integrated Haplotype Score (iHS), and Cross-population ...
155 CitationsSource
#1Rene Urquidez-Romero (Universidad Autónoma de Ciudad Juárez)H-Index: 3
Last. Mauro E. ValenciaH-Index: 22
view all 11 authors...
Diabetes and obesity are major public health concerns of the 21st century.1,2 Both type 2 diabetes (T2D) and obesity are generally believed to result from the interaction between genetic predisposition and environmentally associated lifestyle factors.3,4 The Pima Indians in the US have the highest known prevalence and incidence of T2D in the world.5 In 1991, scientists from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), of the US National Institutes of Health who h...
3 CitationsSource
Cited By1
Newest
#1Robert C. Williams (NIH: National Institutes of Health)H-Index: 1
#2William C. Knowler (NIH: National Institutes of Health)H-Index: 90
Last. Leslie J. Baier (NIH: National Institutes of Health)H-Index: 36
view all 8 authors...
Abstract The Pima Indians of the Gila River Indian Community in Arizona have participated in a long-range study of type 2 diabetes mellitus since 1965 and have been the subject of HLA typing and population studies since the early days of serological assays. These data have been in numerous HLA workshops and conferences and have been the source of at least five novel alleles at the classical HLA loci. In recent time nearly the entire study group was subject to next generation sequencing by whole ...
1 CitationsSource
The prevalence of obesity has increased worldwide in the past ~50 years, reaching pandemic levels. Obesity represents a major health challenge because it substantially increases the risk of diseases such as type 2 diabetes mellitus, fatty liver disease, hypertension, myocardial infarction, stroke, dementia, osteoarthritis, obstructive sleep apnoea and several cancers, thereby contributing to a decline in both quality of life and life expectancy. Obesity is also associated with unemployment, soci...
31 CitationsSource