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Wen-Chi Hsueh
National Institutes of Health
EndocrinologyPopulationGeneticsDiabetes mellitusBiology
76Publications
29H-index
3,186Citations
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Publications 65
Newest
#1Hye In Kim (Regeneron)
#2Nehal Gosalia (Regeneron)H-Index: 4
Last. Clifton Bogardus (NIH: National Institutes of Health)H-Index: 75
view all 11 authors...
Applying whole exome sequencing (WES) to populations with unique genetic architecture has the potential to reveal novel genes and variants associated with traits and diseases. We sequenced and analyzed the exomes of 6,716 individuals from an American Indian population in Southwest US (Southwestern American Indian, or SWAI) with well-characterized metabolic traits. We found that individuals of SWAI have distinct allelic architecture compared to individuals with European and East Asian ancestry, w...
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#1Yunhua L. Muller (NIH: National Institutes of Health)H-Index: 15
#2Robert L. Hanson (NIH: National Institutes of Health)H-Index: 72
Last. Leslie J. Baier (NIH: National Institutes of Health)H-Index: 36
view all 9 authors...
OBJECTIVE: Insulinlike growth factor II (IGF-II) regulates metabolism and growth. In humans, both positive and negative relationships have been reported between serum IGF-II levels and obesity. This study assessed the relationship between serum IGF-II levels and BMI and determined whether IGF-II levels predict weight gain. METHODS: Serum samples were available from 911 American Indians with a recorded BMI. IGF-II was measured using enzyme-linked immunosorbent assay. RESULTS: Serum IGF-II levels ...
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#1Robert L. Hanson (NIH: National Institutes of Health)H-Index: 72
#2Saied SafabakhshH-Index: 1
Last. Robert G. Nelson (NIH: National Institutes of Health)H-Index: 64
view all 14 authors...
Aims/hypothesis Variants in CREBRF (rs12513649 and rs373863828) have been strongly associated with increased BMI and decreased risk of type 2 diabetes in Polynesian populations; the A allele at rs373863828 is common in Polynesians but rare in most other global populations. The aim of the present study was to assess the association of CREBRF variants with obesity and diabetes in Pacific Islander (largely Marianas and Micronesian) populations from Guam and Saipan.
1 CitationsSource
#2Wen-Chi HsuehH-Index: 29
Last. Robert L. HansonH-Index: 72
view all 7 authors...
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#1Robert L. HansonH-Index: 72
Last. William C. KnowlerH-Index: 90
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#1Wen-Chi HsuehH-Index: 29
#2Mary F. WalterH-Index: 15
Last. Robert L. HansonH-Index: 72
view all 5 authors...
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#1Yunhua L. MullerH-Index: 15
#2Robert L. HansonH-Index: 72
Last. Leslie J. BaierH-Index: 36
view all 12 authors...
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#1Wen-Chi Hsueh (NIH: National Institutes of Health)H-Index: 29
#2Peter H. Bennett (NIH: National Institutes of Health)H-Index: 89
Last. Robert L. Hanson (NIH: National Institutes of Health)H-Index: 72
view all 11 authors...
1 CitationsSource
#1Robert L. HansonH-Index: 72
#2Saied SafabakhshH-Index: 1
Last. Wen-Chi HsuehH-Index: 29
view all 8 authors...
A recent genome-wide association study (GWAS) in Samoans (a Polynesian population) identified strong associations of CREBRF variants with BMI. The G allele at rs12513649 (frequency=25.8%) was associated with ∼1.3 kg/m 2 higher BMI per copy, as was the Gln allele at rs373863828 (which codes for an ArgGln substitution). The Gln allele at rs373863828 has frequency of 25.9% in Samoans and is rare in most global populations, although it has been observed at low frequency in some other Oceanic populat...
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#2Mary WalterH-Index: 12
Last. Robert L. HansonH-Index: 72
view all 9 authors...
Inflammatory processes may contribute to type 2 diabetes (T2D), but there is limited information about genetic associations with circulating levels of inflammatory cytokines. We performed a genome-wide association study (GWAS) of cytokines in 1061 nondiabetic Southwestern Native Americans (500 women; 561 men). Fasting serum concentrations of interleukin-6 (IL-6), plasminogen activator inhibitor-1 (PAI-1) and tumor necrosis factor-α (TNF-α) were measured using EMD Millipore assays. Genotypic data...
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