Original paper

Collagen Gly missense mutations: Effect of residue identity on collagen structure and integrin binding

Volume: 203, Issue: 3, Pages: 255 - 262
Published: Sep 1, 2018
Abstract
Gly missense mutations in type I collagen, which replace a conserved Gly in the repeating (Gly-Xaa-Yaa)n sequence with a larger residue, are known to cause Osteogenesis Imperfecta (OI). The clinical consequences of such mutations range from mild to lethal, with more serious clinical severity associated with larger Gly replacement residues. Here, we investigate the influence of the identity of the residue replacing Gly within and adjacent to the...
Paper Details
Title
Collagen Gly missense mutations: Effect of residue identity on collagen structure and integrin binding
Published Date
Sep 1, 2018
Volume
203
Issue
3
Pages
255 - 262
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