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Phase II Randomized Controlled Trial of Constraint-Induced Movement Therapy in Multiple Sclerosis. Part 2: Effect on White Matter Integrity:

Published on Mar 1, 2018in Neurorehabilitation and Neural Repair3.757
· DOI :10.1177/1545968317753073
Ameen Barghi4
Estimated H-index: 4
(Harvard University),
Jane B. Allendorfer12
Estimated H-index: 12
(UAB: University of Alabama at Birmingham)
+ 5 AuthorsVictor W. Mark23
Estimated H-index: 23
(UAB: University of Alabama at Birmingham)
Abstract
Background. Constraint-induced movement therapy (CIMT) is a method of physical rehabilitation that has demonstrated clinical efficacy in patients with chronic stroke, cerebral palsy, and multiple s...
  • References (49)
  • Citations (4)
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References49
Newest
#1Ilse Lamers (University of Hasselt)H-Index: 15
#2Anneleen Maris (University of Hasselt)H-Index: 3
Last. Peter Feys (University of Hasselt)H-Index: 30
view all 7 authors...
Background. There has been an increasing research interest in upper limb rehabilitation in multiple sclerosis (MS). The current changes in the research field inquire a new literature review. Objective. This systematic review aimed to provide an overview of the upper limb rehabilitation strategies in people with MS (PwMS). Methods. Articles published in PubMed and Web of Knowledge were selected when written in English, published in the past 25 years, peer reviewed, that included at least 5 PwMS, ...
29 CitationsSource
#1Jodie K. HaselkornH-Index: 26
#2Christina HughesH-Index: 4
Last. Pushpa NarayanaswamiH-Index: 15
view all 12 authors...
Objective: To systematically review the evidence regarding rehabilitation treatments in multiple sclerosis (MS). Methods: We systematically searched the literature (1970–2013) and classified articles using 2004 American Academy of Neurology criteria. Results: This systematic review highlights the paucity of well-designed studies, which are needed to evaluate the available MS rehabilitative therapies. Weekly home/outpatient physical therapy (8 weeks) probably is effective for improving balance, d...
31 CitationsSource
#1Rita BertoniH-Index: 5
#2Ilse Lamers (University of Hasselt)H-Index: 15
Last. Davide CattaneoH-Index: 19
view all 5 authors...
Background:There has been limited research on upper limb dysfunction in people with multiple sclerosis (PwMS).Objective:The objective of this paper is to study unilateral and bilateral upper limb dysfunction at different International Classification of Functioning (ICF) levels according to overall disability in PwMS.Methods:A total of 105 PwMS (16 with EDSS 6.5 (severe non-ambulant)) were recruited from two rehabilitation centers and assessed in a cross-sectional study.Results:The whole sample s...
32 CitationsSource
#1Jodie K. HaselkornH-Index: 26
#2Christina HughesH-Index: 4
Last. Pushpa NarayanaswamiH-Index: 15
view all 12 authors...
4 CitationsSource
#1Luca ProsperiniH-Index: 26
#2Fulvia FanelliH-Index: 5
Last. Patrizia PantanoH-Index: 45
view all 10 authors...
Microstructural properties of both superior cerebellar peduncles significantly changed after a 12-week intervention aimed at improving balance by using a video game balance board for visual feedback training.
41 CitationsSource
#1Laura Bonzano (UniGe: University of Genoa)H-Index: 21
#2Andrea Tacchino (Multiple Sclerosis Foundation)H-Index: 15
Last. Marco Bove (UniGe: University of Genoa)H-Index: 33
view all 10 authors...
Abstract Upper limb impairments can occur in patients with multiple sclerosis, affecting daily living activities; however there is at present no definite agreement on the best rehabilitation treatment strategy to pursue. Moreover, motor training has been shown to induce changes in white matter architecture in healthy subjects. This study aimed at evaluating the motor behavioral and white matter microstructural changes following a 2-month upper limb motor rehabilitation treatment based on task-or...
57 CitationsSource
#1Tyler Rickards (UAB: University of Alabama at Birmingham)H-Index: 4
#2Chelsey Sterling (UAB: University of Alabama at Birmingham)H-Index: 3
Last. Gitendra Uswatte (UAB: University of Alabama at Birmingham)H-Index: 40
view all 10 authors...
Abstract Objective To investigate the relationship of white matter integrity and path of the corticospinal tract (CST) on arm function before and after constraint-induced (CI) movement therapy in children with hemiparetic cerebral palsy (CP) and adults with chronic stroke. Design Study 1 used a multiple-baseline pre-post design. Study 2 was a randomized controlled trial. Setting Outpatient rehabilitation laboratory. Participants Study 1 included children with hemiparetic CP (n=10; mean age ± SD,...
26 CitationsSource
#1Margaret L. Johnson (University of Montevallo)H-Index: 1
#2Edward Taub (UAB: University of Alabama at Birmingham)H-Index: 77
Last. Gitendra Uswatte (UAB: University of Alabama at Birmingham)H-Index: 40
view all 9 authors...
Purpose The initial version of Constraint-Induced Aphasia Therapy (CIAT I) consisted of a single exercise. This study sought to evaluate the feasibility for future trials of an expanded and restructured protocol designed to increase the efficacy of CIAT I. Method The subjects were 4 native English speakers with chronic stroke who exhibited characteristics of moderate Broca's aphasia. Treatment was carried out for 3.5 hr/day for 15 consecutive weekdays. It consisted of 3 components: (a) intensive...
25 CitationsSource
#1Chelsey SterlingH-Index: 3
#2Edward TaubH-Index: 77
Last. Gitendra Uswatte (UAB: University of Alabama at Birmingham)H-Index: 40
view all 7 authors...
from the present laboratory with adult stroke patients showed that structural neuroplastic changes are correlated with clinical improvements due to constraint-induced movement (CI) ther- apy. This pilot study evaluated whether comparable changes occur in children receiving CI therapy. Ten children (6 boys) with congenital hemiparesis (mean age: 3 years, 3 months) underwent MRI scans 3 weeks before, immediately before, and immediately after receiving 3 weeks of CI therapy. Longitudinal voxel-base...
51 CitationsSource
#1Emilia Sbardella (Sapienza University of Rome)H-Index: 17
#2Francesca TonaH-Index: 13
Last. Patrizia PantanoH-Index: 45
view all 4 authors...
Diffusion tensor imaging (DTI) is an effective means of quantifying parameters of demyelination and axonal loss. The application of DTI in Multiple Sclerosis (MS) has yielded noteworthy results. DTI abnormalities, which are already detectable in patients with clinically isolated syndrome (CIS), become more pronounced as disease duration and neurological impairment increase. The assessment of the microstructural alterations of white and grey matter in MS may shed light on mechanisms responsible f...
72 CitationsSource
Cited By4
Newest
#1Sarah Monteiro dos Anjos (UAB: University of Alabama at Birmingham)H-Index: 1
#2David M. Morris (UAB: University of Alabama at Birmingham)H-Index: 26
Last. Edward Taub (UAB: University of Alabama at Birmingham)H-Index: 77
view all 3 authors...
Constraint-Induced Movement Therapy (CIMT) is comprised of a set of techniques shown to produce significant changes in upper extremity (UE) function following stroke and other disorders. The significant positive results obtained with the UE protocol has led to the development of LE-CIMT, an intervention to improve lower extremity (LE) function. However, some modifications of the UE protocol were needed including: omitting use of a restraint device, development of supervised motor training tasks ...
Source
#1Christoph M. Kanzler (ETH Zurich)H-Index: 2
#2Ilse Lamers (University of Hasselt)H-Index: 15
Last. Olivier Lambercy (ETH Zurich)H-Index: 19
view all 5 authors...
Background: A personalized prediction of upper limb neurorehabilitation outcomes in persons with multiple sclerosis (pwMS) promises to optimize the allocation of therapy and to stratify individuals for resource-demanding clinical trials. Previous research identified predictors on a population level through linear models and clinical data, including conventional assessments describing impaired body functions, such as sensorimotor impairments. The objective of this work was to explore the feasibil...
1 CitationsSource
#1Giacomo BoffaH-Index: 1
#2Andrea Tacchino (Multiple Sclerosis Foundation)H-Index: 15
Last. Matilde Inglese (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 46
view all 11 authors...
Source
#1Alessandro de Sire (University of Eastern Piedmont)H-Index: 1
#2Matteo BigoniH-Index: 6
Last. Alessandro Mauro (UNITO: University of Turin)H-Index: 34
view all 6 authors...
Source
Background:Neural plasticity represents the substrate by which the damaged central nervous system (CNS) re-learns lost behaviors in response to rehabilitation. In persons with multiple sclerosis (M...
1 CitationsSource
#1Laura Bonzano (UniGe: University of Genoa)H-Index: 21
#2Ludovico Pedullà (UniGe: University of Genoa)H-Index: 4
Last. Marco Bove (UniGe: University of Genoa)H-Index: 33
view all 7 authors...
Abstract The aim of this work was to investigate changes in motor performance and in the brain activation pattern during finger movements, following upper limb motor training in multiple sclerosis. Thirty people with multiple sclerosis with mild upper limb sensorimotor deficits were randomly allocated to one of two groups: the experimental group (n = 15) received an upper limb treatment based on voluntary task-oriented movements; the control group (n = 15) underwent passive mobilization of shoul...
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