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Jane B. Allendorfer
University of Alabama at Birmingham
PsychologyEpilepsyAphasiaStrokeAudiology
46Publications
15H-index
543Citations
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#1James T Houston (UAB: University of Alabama at Birmingham)H-Index: 3
#2Jane B. Allendorfer (UAB: University of Alabama at Birmingham)H-Index: 15
Last. Jerzy P. Szaflarski (UAB: University of Alabama at Birmingham)H-Index: 51
view all 5 authors...
White matter pathways associated with language functions include the arcuate (AF), superior longitudinal (SLF), inferior longitudinal (ILF), inferior frontal-occipital (IFOF), and uncinate (UF) fasciculi. Using Tract Based Spatial Statistics (TBSS), we investigated if measurements of white matter integrity in these pathways correlate with linguistic performance. 228 healthy participants (126 female; 146 right-handed), ages 18 to 76, underwent 3.0 Tesla MR diffusion weighted imaging (DWI) and a b...
2 CitationsSource
#1Tyler E. Gaston (UAB: University of Alabama at Birmingham)H-Index: 1
#2Sangeeta Nair (UAB: University of Alabama at Birmingham)H-Index: 2
Last. Jerzy P. Szaflarski (UAB: University of Alabama at Birmingham)H-Index: 51
view all 6 authors...
BACKGROUND: Memory deficits are very common in epilepsy, but no standard of care exists to effectively manage them. OBJECTIVE: We assessed effectiveness of cognitive rehabilitation (CR) on memory and neural plasticity in people with epilepsy (PWE) reporting memory impairments. METHODS: Nine PWE completed 6 weekly sessions adapted from 2 generic CR programs enriched with information regarding epilepsy. Participants completed neuropsychological, mood, and quality of life (QOLIE-31) measures prior ...
Source
#1Sangeeta Nair (UAB: University of Alabama at Birmingham)H-Index: 2
#2Rodolphe Nenert (UAB: University of Alabama at Birmingham)H-Index: 10
Last. Jerzy P. Szaflarski (UAB: University of Alabama at Birmingham)H-Index: 51
view all 7 authors...
Background: Self-generation of material compared to passive learning results in mproved memory performance; this may be related to recruitment of a fronto-temporal encoding network. Using a verbal paired-associate learning fMRI task, we examined the effects of sex, age, and handedness on the neural correlates of self-generation. Methods: Data from 174 healthy English-speaking participants (78M, 56 atypically-handed; ages 19-76) were preprocessed using AFNI and FSL. Independent component analysis...
1 CitationsSource
#1Jane B. Allendorfer (UAB: University of Alabama at Birmingham)H-Index: 15
#2Rodolphe Nenert (UAB: University of Alabama at Birmingham)H-Index: 10
Last. Jerzy P. Szaflarski (UAB: University of Alabama at Birmingham)H-Index: 51
view all 9 authors...
Abstract Patients with treatment-resistant epilepsy (TRE) frequently exhibit memory and attention deficits that contribute to their poor personal and societal outcomes. We studied the effects of adjunct treatment with pharmaceutical grade cannabidiol (CBD) oral solution (Epidiolex®; Greenwich Biosciences, Inc.) on attention control processes related to stimulus conflict resolution in patients with TRE. Twenty-two patients with TRE underwent 3 T magnetic resonance imaging (MRI) before receiving (...
1 CitationsSource
#1Jane B. Allendorfer (UAB: University of Alabama at Birmingham)H-Index: 15
#2Gabrielle A. Brokamp (UAB: University of Alabama at Birmingham)H-Index: 1
Last. Marcas M. Bamman (UAB: University of Alabama at Birmingham)H-Index: 43
view all 12 authors...
Abstract Memory impairment is common in persons with epilepsy (PWE), and exercise may be a strategy for its improvement. In this pilot study, we hypothesized that exercise rehabilitation would improve physical fitness and verbal memory and induce changes in brain networks involved in memory processes. We examined the effects of combined endurance and resistance exercise rehabilitation on memory and resting state functional connectivity (rsFC). Participants were randomized to exercise (PWE-E) or ...
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#1Adam M. Goodman (UAB: University of Alabama at Birmingham)H-Index: 7
#2Jane B. Allendorfer (UAB: University of Alabama at Birmingham)H-Index: 15
Last. Jerzy P. SzaflarskiH-Index: 51
view all 8 authors...
: Patients with epilepsy are often able to predict seizure occurrence subsequent to an acute stress experience. However, neuroimaging investigations into the neural basis of this relationship or the potential influence of perceived life stress are limited. The current study assessed the relationship between perceived stress and the neurobehavioral response to stress in patients with left temporal lobe epilepsy (LTLE) and healthy controls (HCs) using heart rate, salivary cortisol level, and funct...
1 CitationsSource
#1Ayushe A. Sharma (UAB: University of Alabama at Birmingham)H-Index: 1
#2Rodolphe Nenert (UAB: University of Alabama at Birmingham)H-Index: 10
Last. Jerzy P. Szaflarski (UAB: University of Alabama at Birmingham)H-Index: 51
view all 7 authors...
Abstract Cannabis use is associated with changes in brain structure and function; its neurotoxic effects are largely attributed to Δ9-tetrahydrocannabidiol. Whether such effects are present in patients with epilepsy exposed to a highly-purified cannabidiol isolate (CBD; Epidiolex®; Greenwich Biosciences, Inc.) has not been investigated to date. This preliminary study examines whether daily CBD dose of 15–25 mg/kg produces cerebral macrostructure changes and, if present, how they relate to change...
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#1Jane B. Allendorfer (UAB: University of Alabama at Birmingham)H-Index: 15
#2Rodolphe Nenert (UAB: University of Alabama at Birmingham)H-Index: 10
Last. Jerzy P. Szaflarski (UAB: University of Alabama at Birmingham)H-Index: 51
view all 9 authors...
Abstract We investigated psychological stress response in the brain regions involved in emotion-motor-executive control in psychogenic non-epileptic seizures (PNES). 12 PNES patients and 12 healthy controls (HCs) underwent stress task and resting state functional MRI (fMRI), mood and quality of life (QOL) assessments, and measurements of salivary cortisol, alpha-amylase, and heart rate. Group differences were assessed, and we correlated beta values from a priori selected brain regions showing st...
2 CitationsSource
#1Lauren B. Bolden (UAB: University of Alabama at Birmingham)H-Index: 3
#2Joseph C. Griffis (UAB: University of Alabama at Birmingham)H-Index: 8
Last. Jerzy P. Szaflarski (UAB: University of Alabama at Birmingham)H-Index: 51
view all 5 authors...
Abstract Previously, we demonstrated an association between cortical hyperexcitability and mood disturbance in healthy adults. Studies have documented hyperexcitability in patients with idiopathic generalized epilepsies (IGEs; long-interval intracortical inhibition [LICI]) and high prevalence of mood comorbidities. This study aimed to investigate the influences of cortical excitability and seizure control on mood state in patients with IGEs. Single and paired-pulse transcranial magnetic stimulat...
Source
#1Lauren B. Bolden (UAB: University of Alabama at Birmingham)H-Index: 3
#2Joseph C. Griffis (UAB: University of Alabama at Birmingham)H-Index: 8
Last. Jerzy P. Szaflarski (UAB: University of Alabama at Birmingham)H-Index: 51
view all 5 authors...
Abstract We recently found that higher cortical excitability is associated with poorer attention performance in healthy adults. While patients with idiopathic generalized epilepsies (IGEs), previously termed genetic generalized epilepsies, are known to demonstrate increased cortical excitability and cognitive deficits, a relationship between these variables in IGEs has not been investigated. Therefore, we aimed to characterize the effects of cortical excitability and seizure control on cognitive...
2 CitationsSource
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