Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice
Abstract
Aging is the largest risk factor for cardiovascular disease, yet the molecular mechanisms underlying vascular aging remain unclear. Mitochondrial DNA (mtDNA) damage is linked to aging, but whether mtDNA damage or mitochondrial dysfunction is present and directly promotes vascular aging is unknown. Furthermore, mechanistic studies in mice are severely hampered by long study times and lack of sensitive, repeatable and reproducible parameters of...
Paper Details
Title
Restoring mitochondrial DNA copy number preserves mitochondrial function and delays vascular aging in mice
Published Date
May 9, 2018
Journal
Volume
17
Issue
4
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