Aging Cell
Papers 1930
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#1Lalhaba Oinam (University of Tsukuba)H-Index: 2
#2Gopakumar Changarathil (University of Tsukuba)H-Index: 1
Last. Hiromi Yanagisawa (University of Tsukuba)H-Index: 36
view all 7 authors...
Aging in the epidermis is marked by a gradual decline in barrier function, impaired wound healing, hair loss, and an increased risk of cancer. This could be due to age-related changes in the properties of epidermal stem cells and defective interactions with their microenvironment. Currently, no biochemical tools are available to detect and evaluate the aging of epidermal stem cells. The cellular glycosylation is involved in cell-cell communications and cell-matrix adhesions in various physiologi...
#1Oyundari Amartuvshin (NDMC: National Defense Medical Center)H-Index: 1
#2Chi-Hung LinH-Index: 1
Last. Bai‐Shiou Hsiao (NTNU: National Taiwan Normal University)
view all 17 authors...
Changes in mitochondrial dynamics (fusion and fission) are known to occur during stem cell differentiation; however, the role of this phenomenon in tissue aging remains unclear. Here, we report that mitochondrial dynamics are shifted toward fission during aging of Drosophila ovarian germline stem cells (GSCs), and this shift contributes to aging-related GSC loss. We found that as GSCs age, mitochondrial fragmentation and expression of the mitochondrial fission regulator, Dynamin-related protein ...
#1Weizhe Zhong (Nanjing Medical University)H-Index: 1
#2Zhuqing Rao (Nanjing Medical University)H-Index: 3
Last. Xuehao Wang (Nanjing Medical University)H-Index: 30
view all 10 authors...
Although aggravated liver injury has been reported in aged livers post-ischemia and reperfusion (IR), the underlying mechanism of innate immune activation of aged macrophages is not well understood. Here, we investigated whether and how Stimulator of interferon genes (STING) signaling regulated macrophage proinflammatory activation and liver IR injury. Mice were subjected to hepatic IR in vivo. Macrophages isolated from IR-stressed livers and bone marrow-derived macrophages (BMDMs) from young an...
#1Colby Stotesbury (Thomas Jefferson University)H-Index: 2
#2Eric B. Wong (Thomas Jefferson University)H-Index: 3
Last. Luis J. Sigal (Thomas Jefferson University)H-Index: 25
view all 7 authors...
It is known that aging decreases natural resistance to viral diseases due to dysfunctional innate and adaptive immune responses, but the nature of these dysfunctions, particularly in regard to innate immunity, is not well understood. We have previously shown that C57BL/6J (B6) mice lose their natural resistance to footpad infection with ectromelia virus (ECTV) due to impaired maturation and recruitment of natural killer (NK) cells to the draining popliteal lymph node (dLN). More recently, we hav...
#1Beatriz Gomez-Santos (UPV/EHU: University of the Basque Country)H-Index: 3
#2Diego Saenz de Urturi (UPV/EHU: University of the Basque Country)H-Index: 1
Last. Águeda González-Rodríguez (ISCIII: Carlos III Health Institute)H-Index: 23
view all 20 authors...
Osteopontin (OPN), a senescence-associated secretory phenotype factor, is increased in patients with nonalcoholic fatty liver disease (NAFLD). Cellular senescence has been associated with age-dependent hepatosteatosis. Thus, we investigated the role of OPN in the age-related hepatosteatosis. For this, human serum samples, animal models of aging, and cell lines in which senescence was induced were used. Metabolic fluxes, lipid, and protein concentration were determined. Among individuals with a n...
#1Wenjing Liang (UM: University of Montana)
#2Alexandra G. Moyzis (UM: University of Montana)H-Index: 3
Last. Åsa B. Gustafsson (UM: University of Montana)H-Index: 46
view all 6 authors...
Advancing age is a major risk factor for developing heart disease, and the biological processes contributing to aging are currently under intense investigation. Autophagy is an important cellular quality control mechanism that is reduced in tissues with age but the molecular mechanisms underlying the age-associated defects in autophagy remain poorly characterized. Here, we have investigated how the autophagic process is altered in aged mouse hearts. We report that autophagic activity is reduced ...
#1Wen-Yu Lien (NTU: National Taiwan University)H-Index: 1
#2Yu-Ting Chen (NTU: National Taiwan University)
Last. Chia-Lin Wu (CGU: Chang Gung University)H-Index: 10
view all 12 authors...
Brain function has been implicated to control the aging process and modulate lifespan. However, continuous efforts remain for the identification of the minimal sufficient brain region and the underlying mechanism for neuronal regulation of longevity. Here, we show that the Drosophila lifespan is modulated by rab27 functioning in a small subset of neurons of the mushroom bodies (MB), a brain structure that shares analogous functions with mammalian hippocampus and hypothalamus. Depleting rab27 in ...
#1Ramya PotabattulaH-Index: 4
#2Federica Zacchini (Jagiellonian University)H-Index: 10
Last. Andrea Lucas-Hahn (Friedrich Loeffler Institute)H-Index: 5
view all 13 authors...
In somatic cells/tissues, methylation of ribosomal DNA (rDNA) increases with age and age-related pathologies, which has a direct impact on the regulation of nucleolar activity and cellular metabolism. Here, we used bisulfite pyrosequencing and show that methylation of the rDNA transcription unit including upstream control element (UCE), core promoter, 18S rDNA, and 28S rDNA in human sperm also significantly increases with donor's age. This positive correlation between sperm rDNA methylation and ...
Paternal aging and the prevalence of neurodevelopmental disorders in offspring are well documented. Yet, the underlying mechanism and the mode of inheritance have not been conclusively established. Advancing paternal age is a subtle and varying phenotype. As such, it is likely that a threshold for cumulative risk may exist that, if surpassed, culminates in a predisposition to disease and ultimately an observed phenotype in offspring. Epigenetic regulation provides a plausible explanation for the...
#1Marie-Françoise Montaron (University of Bordeaux)H-Index: 15
#2Vanessa Charrier (University of Bordeaux)H-Index: 6
Last. Djoher Nora Abrous (University of Bordeaux)H-Index: 44
view all 5 authors...
During aging, some individuals are resilient to the decline of cognitive functions whereas others are vulnerable. These inter-individual differences in memory abilities have been associated with differences in the rate of hippocampal neurogenesis measured in elderlies. Whether the maintenance of the functionality of neurons generated throughout adult life is linked to resilience to cognitive aging remains completely unexplored. Using the immediate early gene Zif268, we analyzed the activation of...
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