Martin R. Bennett
University of Cambridge
Publications 300
#1Kazuhiro Dan (MedStar Washington Hospital Center)H-Index: 1
#2Hector M. Garcia-Garcia (MedStar Washington Hospital Center)H-Index: 67
Last.Michael Mahmoudi (University Hospital Southampton NHS Foundation Trust)H-Index: 11
view all 10 authors...
Deoxyribonucleic acid (DNA) damage and repair signaling cascades are related to the development of atherosclerosis. Pathological studies have demonstrated that healed coronary plaque rupture (HCPR) contributes to plaque progression and predisposes to sudden ischemic cardiac death. The objective of this study is to investigate the relationship between HCPR detected by optical coherence tomography (OCT) and DNA ligase. Forty-two patients with both OCT and DNA ligase were prospectively enrolled. Th...
#1Jennifer L. Harman (University of Cambridge)H-Index: 3
#2Lina Dobnikar (University of Cambridge)H-Index: 2
Last.Helle F. Jørgensen (University of Cambridge)H-Index: 21
view all 15 authors...
Objective: Vascular inflammation underlies cardiovascular disease. Vascular smooth muscle cells (VSMCs) upregulate selective genes, including MMPs (matrix metalloproteinases) and proinflammatory cy...
1 CitationsSource
#1Nikunj Shah (University of Surrey)H-Index: 2
#2Lisiane B. Meira (University of Surrey)H-Index: 28
Last.Michael Mahmoudi (University of Southampton)H-Index: 11
view all 14 authors...
Abstract Objective The aim of this study was to examine DNA ligase activity and expression of DNA damage response pathway (DDR) genes in patients with stable angina (SA) and non-ST elevation myocardial infarction (NSTEMI) and determine whether they correlate with plaque morphology. Background Patients with coronary artery disease (CAD) have evidence of deoxyribonucleic acid (DNA) damage in peripheral blood mononuclear cells (PBMCs). It is unclear whether this represents excess damage or defectiv...
#1Johannes Bargehr (University of Cambridge)H-Index: 5
#2Lay Ping Ong (University of Cambridge)H-Index: 1
Last.Sanjay Sinha (University of Cambridge)H-Index: 21
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The epicardium and its derivatives provide trophic and structural support for the developing and adult heart. Here we tested the ability of human embryonic stem cell (hESC)-derived epicardium to augment the structure and function of engineered heart tissue in vitro and to improve efficacy of hESC-cardiomyocyte grafts in infarcted athymic rat hearts. Epicardial cells markedly enhanced the contractility, myofibril structure and calcium handling of human engineered heart tissues, while reducing pas...
5 CitationsSource
#1Charis Costopoulos (University of Cambridge)H-Index: 16
#2Akiko MaeharaH-Index: 43
Last.Martin R. Bennett (University of Cambridge)H-Index: 66
view all 8 authors...
Abstract Objectives This study sought to determine if plaque structural stress (PSS) and other plaque stress parameters are increased in plaques that cause future major adverse cardiovascular events (MACE) and if incorporating these parameters improves predictive capability of intravascular ultrasonography (IVUS). Background Less than 10% of coronary plaques identified as high-risk by intravascular imaging result in subsequent MACE. Thus, more specific measurements of plaque vulnerability are re...
#1Gemma Basatemur (University of Cambridge)H-Index: 4
#2Helle F. Jørgensen (University of Cambridge)H-Index: 21
Last.Ziad Mallat (University of Cambridge)H-Index: 73
view all 5 authors...
Vascular smooth muscle cells (VSMCs) are a major cell type present at all stages of an atherosclerotic plaque. According to the ‘response to injury’ and ‘vulnerable plaque’ hypotheses, contractile VSMCs recruited from the media undergo phenotypic conversion to proliferative synthetic cells that generate extracellular matrix to form the fibrous cap and hence stabilize plaques. However, lineage-tracing studies have highlighted flaws in the interpretation of former studies, revealing that these stu...
8 CitationsSource
#1Marc Clement (University of Cambridge)H-Index: 15
#2Joel Chappell (University of Cambridge)H-Index: 2
Last.Ziad Mallat (University of Cambridge)H-Index: 73
view all 13 authors...
Objective— Recent studies suggested the occurrence of phenotypic switching of vascular smooth muscle cells (VSMCs) during the development of aortic aneurysm (AA). However, lineage-tracing studies a...
1 CitationsSource
#1Charis Costopoulos (University of Cambridge)H-Index: 16
#2Lucas H. Timmins (Georgia Institute of Technology)H-Index: 14
Last.Martin R. Bennett (University of Cambridge)H-Index: 66
view all 11 authors...
3 CitationsSource
Myocardial infarction (MI) healing occurs in 2 phases: first an inflammatory phase, where clearance of necrotic debris occurs, followed by a reparative phase characterized by angiogenesis, granulation tissue formation, and attempts to repair the extracellular matrix. While efficient healing relies