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Subtle esophageal motility alterations in Parkinsonian Syndromes: synucleinopathies vs. tauopathies.

Published on Jul 1, 2018in Movement Disorders Clinical Practice
· DOI :10.1002/mdc3.12616
Inga Claus3
Estimated H-index: 3
,
Judith Suttrup1
Estimated H-index: 1
+ 5 AuthorsTobias Warnecke24
Estimated H-index: 24
Abstract
  • References (39)
  • Citations (0)
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References39
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#1Christina Pflug (UHH: University of Hamburg)H-Index: 3
#2Moritz Bihler (UHH: University of Hamburg)H-Index: 2
Last. Carsten Buhmann (UHH: University of Hamburg)H-Index: 23
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To assess the prevalence of dysphagia and its typical findings in unselected “real-world” Parkinson patients using an objective gold-standard method. This was a prospective, controlled, cross-sectional study conducted in 119 consecutive Parkinson patients of all stages independent of subjective dysphagia. Patients and 32 controls were clinically and endoscopically examined by flexible endoscopic evaluation of swallowing (FEES) to evaluate the deglutition with regard to three consistencies (water...
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#1Günter U. Höglinger (German Center for Neurodegenerative Diseases)H-Index: 40
#2Gesine Respondek (German Center for Neurodegenerative Diseases)H-Index: 12
Last. Irene LitvanH-Index: 79
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Background: PSP is a neuropathologically defined disease entity. Clinical diagnostic criteria, published in 1996 by the National Institute of Neurological Disorders and Stroke/Society for PSP, have excellent specificity, but their sensitivity is limited for variant PSP syndromes with presentations other than Richardson's syndrome. Objective: We aimed to provide an evidence- and consensus-based revision of the clinical diagnostic criteria for PSP. Methods: We searched the PubMed, Cochrane, Medlin...
241 CitationsSource
#1Inga ClausH-Index: 3
#2Anna HeidbrederH-Index: 7
Last. Tobias WarneckeH-Index: 24
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2 CitationsSource
#1Andrew Su (Stanford University)H-Index: 5
#2Rita GandhyH-Index: 5
Last. George Triadafilopoulos (Stanford University)H-Index: 54
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#1Inga SuttrupH-Index: 7
#2Judith Suttrup (KNAW: Royal Netherlands Academy of Arts and Sciences)H-Index: 1
Last. Tobias WarneckeH-Index: 24
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Background Dysphagia is a clinically relevant symptom in patients with Parkinson's disease (PD) leading to pronounced reduction in quality of life and other severe complications. Parkinson's disease-related dysphagia may affect the oral and pharyngeal, as well as the esophageal phase of swallowing. Methods To examine the nature and extend of esophageal dysphagia in different stages of PD and their relation to oropharyngeal dysfunction, we examined 65 PD patients (mean age 66.3±9.7 years, mean di...
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#1Morten Gersel Stokholm (Aarhus University Hospital)H-Index: 7
#2E. H. Danielsen (Aarhus University Hospital)H-Index: 19
Last. Per Borghammer (Aarhus University Hospital)H-Index: 23
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Objective It has been hypothesized that Lewy pathology initiates in the enteric nervous system years prior to debut of clinical motor symptoms in Parkinson disease patients. This study investigates whether Lewy pathology is present in various gastrointestinal tract tissues from Parkinson disease patients in the prodromal phase. Methods We used the Danish National Pathology Registry to identify archived paraffin-embedded tissue blocks from 57 Parkinson disease patients (98 blocks) and 90 control ...
96 CitationsSource
#1Dexi DuH-Index: 1
#2Tao SongH-Index: 1
Last. Shixiu WuH-Index: 1
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Summary Concurrent chemoradiotherapy (CCRT) has been accepted as the standard non-surgical treatment for esophageal cancer. However, no consistent conclusions have been reached whether elective lymph node irradiation (ENI) should be delivered. Therefore, we performed a systematic review and pooled analysis to evaluate the value of CCRT with ENI. A literature search based on PubMed, Embase and Google Scholar was carried out and all of the studies were evaluated carefully regarding with survival o...
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More than 80 % of patients with Parkinson’s disease (PD) develop dysphagia during the course of their disease. Swallowing impairment reduces quality of life, complicates medication intake and leads to malnutrition and aspiration pneumonia, which is a major cause of death in PD. Although the underlying pathophysiology is poorly understood, it has been shown that dopaminergic and non-dopaminergic mechanisms are involved in the development of dysphagia in PD. Clinical assessment of dysphagia in PD ...
56 CitationsSource
#1Ronald B. Postuma (MGH: Montreal General Hospital)H-Index: 53
#2Daniela Berg (German Center for Neurodegenerative Diseases)H-Index: 35
Last. Günther Deuschl (CAU: University of Kiel)H-Index: 32
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This document presents the Movement Disorder Society Clinical Diagnostic Criteria for Parkinson's disease (PD). The Movement Disorder Society PD Criteria are intended for use in clinical research but also may be used to guide clinical diagnosis. The benchmark for these criteria is expert clinical diagnosis; the criteria aim to systematize the diagnostic process, to make it reproducible across centers and applicable by clinicians with less expertise in PD diagnosis. Although motor abnormalities r...
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#1Stéphane Derrey (University of Rouen)H-Index: 14
#2Nathalie Chastan (University of Rouen)H-Index: 5
Last. Guillaume Gourcerol (University of Rouen)H-Index: 16
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Background Bilateral subthalamic nucleus (STN) stimulation is used to alleviate Parkinson's disease (PD) motor symptoms. Recently, it has been shown that this therapeutic also increased gut cholinergic contractions. We therefore investigated the effect of STN stimulation on esophageal motility in an interventional randomized study. Methods Sixteen humans PD patients (4 women, 12 men; age: 62.4 ± 9.3-years old) who underwent STN stimulation for at least 6 months were randomly evaluated with eithe...
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