Original paper

Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development

Volume: 116, Issue: 16, Pages: 7793 - 7798
Published: Apr 1, 2019
Abstract
Reduction of native prion protein (PrP) levels in the brain is an attractive strategy for the treatment or prevention of human prion disease. Clinical development of any PrP-reducing therapeutic will require an appropriate pharmacodynamic biomarker: a practical and robust method for quantifying PrP, and reliably demonstrating its reduction in the central nervous system (CNS) of a living patient. Here we evaluate the potential of ELISA-based...
Paper Details
Title
Prion protein quantification in human cerebrospinal fluid as a tool for prion disease drug development
Published Date
Apr 1, 2019
Volume
116
Issue
16
Pages
7793 - 7798
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