Original paper
Correlated Single Molecule Twist and Fluorescence Measurements on CRISPR/Cas Systems
Abstract
CRISPR/Cas systems are RNA-guided ribonucleoprotein (RNP) complexes with nuclease activity that provide prokaryotes with an adaptive defense mechanism against foreign nucleic acids. The RNP complex recognizes complementary target sites by base-pairing its RNA component with one of the strands of the target DNA while displacing the other one forming a so-called R-loop structure. After completion of the R-loop formation, the target DNA is cleaved...
Paper Details
Title
Correlated Single Molecule Twist and Fluorescence Measurements on CRISPR/Cas Systems
Published Date
Feb 1, 2018
Journal
Volume
114
Issue
3
Pages
250a - 250a
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Notes
History