Cigarette smoke enhances oncogene addiction to c‐ MET and desensitizes EGFR ‐expressing non‐small cell lung cancer to EGFR TKI s

Cigarette smoking is one of the leading risks for lung cancer and is associated with the insensitivity of non‐small cell lung cancer ( NSCLC ) to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors ( TKI s). However, it remains undetermined whether and how cigarette smoke affects the therapeutic efficacy of EGFR TKI s. In this study, our data showed that chronic exposure to cigarette smoke extract ( CSE ) or tobacco smoke‐derived...