Wei Chien Huang
China Medical University (PRC)
Publications 59
Although dual EGFR/HER2 tyrosine kinase inhibitor lapatinib has provided effective clinical benefits for HER2-positive breast cancer patients, acquired resistance to this drug remains a major concern. Thus, the development of alternative therapeutic strategies is urgently needed for patients who failed lapatinib treatment. Proteasome inhibitors have been reported to possess high anti-tumor activity to breast cancer cells. Therefore, this study aims to examine whether and how proteasome inhibitor...
#1Huiquan Liu (HUST: Huazhong University of Science and Technology)
#2Ayse Ertay (University of Southampton)
Last.Yi-HuaWang (University of Southampton)H-Index: 17
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Abstract Lung cancers have a predilection for metastasizing to bone. The matricellular glycoprotein thrombospondin (TSP)-2 regulates multiple biological functions and has a critical role in tumor development and metastasis, although its effects are uncertain in lung cancer bone metastasis. This study demonstrates that TSP-2 expression is highly correlated with lung cancer tumor stage and that the TSP-2 neutralizing antibody reduces osteoclast formation in conditioned medium obtained from lung ca...
#1Yi Chen Yang (National Taichung University of Science and Technology)H-Index: 1
#2Pei Chen Chiou (PRC: China Medical University (PRC))
Last.Chih-Hsin TangH-Index: 46
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#1Pei-Chih Lee (University of Texas MD Anderson Cancer Center)H-Index: 1
#2Yueh-Fu FangH-Index: 4
Last.Mien Chie Hung (PRC: China Medical University (PRC))H-Index: 97
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Summary Multiple mechanisms of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been identified in EGFR-mutant non-small cell lung cancer (NSCLC); however, recurrent resistance to EGFR TKIs due to the heterogeneous mechanisms underlying resistance within a single patient remains a major challenge in the clinic. Here, we report a role of nuclear protein kinase Cδ (PKCδ) as a common axis across multiple known TKI-resistance mechanisms. Specifically, we d...
#1Chih Yen Tu (PRC: China Medical University (PRC))H-Index: 19
#2Fang‐Ju Cheng (PRC: China Medical University (PRC))H-Index: 1
Last.Wei Chien HuangH-Index: 20
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#1Changwei Dou (Xi'an Jiaotong University)H-Index: 2
#2Zhikui Liu (Xi'an Jiaotong University)H-Index: 1
Last.Ningling Kang (UMN: University of Minnesota)H-Index: 12
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Background & Aims Hepatic stellate cells (HSCs) contribute to desmoplasia and stiffness of liver metastases by differentiating into matrix-producing myofibroblasts. We investigated whether stiffness due to the presence of tumors increases activation of HSCs into myofibroblasts and their tumor-promoting effects, as well as the role of E1A binding protein p300, a histone acetyltransferase that regulates transcription, in these processes. Methods HSCs were isolated from liver tissues of patients, m...