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Molecular Oncology
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Papers 1443
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#1Tao Wei (ZJU: Zhejiang University)H-Index: 9
#2Jian Zhang (ZJU: Zhejiang University)H-Index: 27
Last. Tao Ma (ZJU: Zhejiang University)H-Index: 15
view all 17 authors...
Cell-free DNA (cfDNA) offers an alternative to tissue biopsies for genomic profiling in tumors. Here, we sought to evaluate copy number alterations in PDAC through whole-genome sequencing (WGS) of cfDNA and determine their clinical significance. Using shallow WGS across 90 plasma samples from 70 pancreatic cancer patients, we detected somatic copy number alterations (CNAs) in 34 subjects (48.6%). Additionally, a higher tumor fraction (TFx) was associated with increased carbohydrate antigen 19-9 ...
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#1Kinga Molnár (University of Szeged)H-Index: 1
#2Ádám Mészáros (University of Szeged)H-Index: 2
Last. János HaskóH-Index: 10
view all 12 authors...
Brain metastases are life-threatening complications of triple negative breast cancer, melanoma and a few other tumor types. Poor outcome of cerebral secondary tumors largely depends on the microenvironment formed by cells of the neurovascular unit, among which pericytes are the least characterized. By using in vivo and in vitro techniques and human samples, here we show that pericytes play crucial role in the development of metastatic brain tumors by directly influencing key steps of the develop...
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A hallmark of ovarian high grade serous carcinoma (HGSC) is its early and massive peritoneal dissemination via the peritoneal fluid. It is generally believed that tumor cells must breech the mesothelium of peritoneal organs to adhere to the underlying extracellular matrix (ECM) and initiate metastatic growth. However, the molecular mechanisms underlying these processes are only partially understood. Here, we have analyzed 52 matched samples of spheroids and solid tumor masses (suspected primary ...
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#1Emil Aagaard Thomsen (AU: Aarhus University)H-Index: 2
#2Anne Bruun Rovsing (AU: Aarhus University)
Last. MikkelsenJacob Giehm (AU: Aarhus University)H-Index: 30
view all 8 authors...
Diffuse large B-cell lymphoma (DLBCL) is characterized by extensive genetic heterogeneity, and this results in unpredictable responses to the current treatment, R-CHOP, which consists of a cancer drug combination supplemented with the humanized CD20-targeting monoclonal antibody rituximab. Despite improvements in the patient response rate through rituximab addition to the treatment plan, up to 40% of DLBCL patients end in a relapsed or refractory state due to inherent or acquired resistance to t...
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#1Stanislav Drápela (Masaryk University)H-Index: 1
#2Prashant Khirsariya (Masaryk University)H-Index: 2
Last. William Watson (UCD: University College Dublin)H-Index: 13
view all 14 authors...
As treatment options for patients with incurable metastatic castration-resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic options are needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein kinase implicated in the DNA damage response (DDR) pathway that prevents the accumulation of DNA damage and controls regular genome duplication. CHK1 has been associated with prostate cancer (PCa) induction, progression, and lethality, hence CHK1 inhibitors SCH900...
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#1Sheng Yang (SEU: Southeast University)H-Index: 6
#2Tong Liu (SEU: Southeast University)H-Index: 5
Last. Geyu Liang (SEU: Southeast University)H-Index: 16
view all 3 authors...
Few studies have examined the association between smoking status (including former smokers) at diagnosis and overall survival among cancer patients. We aimed to assess the benefits of quitting smoking on cancer prognosis in cohorts of cancer patient smokers obtained from the Cancer Genome Atlas (TCGA) database. Hazard ratios (HR) were calculated to evaluate smoking behavior at cancer diagnosis (reformed smokers vs. current smokers) in association with overall survival using multivariate-adjusted...
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#1Chun-Hao Pan (SBU: Stony Brook University)H-Index: 1
#2Yuka Otsuka (Scripps Research Institute)
Last. David K. Chang (Glas.: University of Glasgow)H-Index: 40
view all 15 authors...
Pancreatic ductal adenocarcinoma (PDAC) is predicted to become the second leading cause of cancer-related deaths in the United States by 2020, due in part to innate resistance to widely used chemotherapeutic agents and limited knowledge about key molecular factors that drive tumor aggression. We previously reported a novel negative prognostic biomarker, keratin 17 (K17), whose overexpression in cancer results in shortened patient survival. In this study, we aimed to determine the predictive valu...
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#1Yujiro Hayashi (Osaka University)H-Index: 25
#2Kazutoshi Fujita (Osaka University)H-Index: 24
Last. Taigo Kato (Osaka University)H-Index: 12
view all 17 authors...
TERT promoter mutations are frequently found in tumors or urine from patients with urothelial carcinoma (UC). TERT promoter mutations are also detected in urine from patients with no evidence of cancer but are associated with subsequent UC development. Mutations in the TERT promoter are thought to be present in non-malignant urothelium during early stages of tumor formation prior to pathological change, but this has not been proven directly. In this proof-of-concept study, we investigated the cl...
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#1Jie Sun (Nanjing Medical University)H-Index: 1
#2Dongju Feng (Nanjing Medical University)H-Index: 7
Last. Qing Shao (Nanjing Medical University)H-Index: 4
view all 8 authors...
: Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. The clinical efficacy of vincristine (VCR) in the treatment of RB is severely limited by drug resistance. Here, we found that CD24, a GPI-anchored protein, was overexpressed in human RB tissues and RB cell lines, and was associated with the sensitivity of RB cells in response to VCR therapy. We demonstrated that CD24 plays a critical role in impairing RB sensitivity to VCR via regulating autophagy. Mechanistically, C...
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#1Vincent GrégoireH-Index: 57
#2Matthias Guckenberger (UZH: University of Zurich)H-Index: 51
Last. Marcel van Herk (University of Manchester)H-Index: 60
view all 11 authors...
The key goal and main challenge of radiation therapy is the elimination of tumours without any concurring damages of the surrounding healthy tissues and organs. Radiation doses required to achieve sufficient cancer-cell kill exceed in most clinical situations the dose that can be tolerated by the healthy tissues, especially when large parts of the affected organ are irradiated. High precision radiation oncology aims at optimizing tumor coverage, while sparing normal tissues. Medical imaging duri...
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