Original paper
Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis
Abstract
Blood cell formation is classically thought to occur through a hierarchical differentiation process, although recent studies have shown that lineage commitment may occur earlier in hematopoietic stem and progenitor cells (HSPCs). The relevance to human blood diseases and the underlying regulation of these refined models remain poorly understood. By studying a genetic blood disorder, Diamond-Blackfan anemia (DBA), where the majority of mutations...
Paper Details
Title
Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis
Published Date
Mar 1, 2018
Journal
Volume
173
Issue
1
Pages
90 - 103.e19
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Notes
History