Expression of Progesterone and Androgen Receptors in the Breast of Premenopausal Women, Considering Menstrual Phase

Progesterone and androgens are important for normal development and tumorigenesis of the breast.Breast tissue samples from 49 premenopausal women were obtained. The progesterone receptors (PRA, PRB, PGRMC1 and PGRMC2) and the androgen receptor (AR) were determined in malignant and benign breast tumors and control tissues.The PRB and AR mRNA levels were highest in tumors. PGRMC1 and PGRMC2 mRNA levels were higher in malignant tumors compared to...