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Anticancer Research
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#1Dongchan KimH-Index: 2
#2Youngil Koh (Seoul National University Hospital)H-Index: 14
Last. Sung-Soo YoonH-Index: 33
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BACKGROUND/AIM: The aim of the study was to examine the efficacy of the combination of anaplastic lymphoma kinase (ALK) inhibitors with other inhibitors for the treatment of ALK-positive lymphomas. This approach is predicted to be an alternative way for suppressing ALK-positive anaplastic large cell lymphoma (ALCL). MATERIALS AND METHODS: We treated ALK-positive ALCL cell lines, KARPAS-299 and SU-DHL-1, with the ALK inhibitor alectinib and the mammalian target of rapamycin (mTOR) inhibitor evero...
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#1Takuma HayashiH-Index: 7
#2Kenji SanoH-Index: 22
Last. Ikuo KonishiH-Index: 50
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BACKGROUND/AIM: Uterine leiomyosarcoma (Ut-LMS) is a refractory tumor that repeatedly recurs with hematogenous metastasis, which may be due to the presence of drug-resistant tumor stem cells. Its treatment is limited to surgical procedures. We previously reported that Ut-LMS spontaneously developed in mice deficient in the proteasome component low-molecular mass polypeptide 2 (LMP2). We showed that LMP2 expression was significantly attenuated specifically in human Ut-LMS. The aim of this study w...
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#1Peter P. Sordillo (Lenox Hill Hospital)H-Index: 1
#1Peter P. SordilloH-Index: 21
Last. Laura A. SordilloH-Index: 11
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The majority of patients receiving chemotherapy experience post-chemotherapy cognitive impairment, sometimes referred to as "chemo brain" or "chemo fog." The cognitive impairment associated with this syndrome can be severe, and can sometimes last for many years after therapy discontinuation. Despite extensive investigations, its etiology is unknown. We argue that chemo brain results from damage to tubulin within microtubules. This damage can occur directly from tubulin inhibitors such as taxanes...
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AIM: We attempted to clarify the role of Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligand, troglitazone (TRO) on oral squamous cell carcinoma (SCC). MATERIALS AND METHODS: The expression of PPARgamma gene was examined in 47 human oral SCC tissues and two human oral SCC cell lines, CA9-22 and HSC-4. The effects of TRO on the growth and cell-cycle progression of human oral SCC cells were examined. RESULTS: PPARgamma mRNA was detected in 20 of 47 oral SCC tissues and two ...
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#1Adriana C. VidalH-Index: 22
#2Frank DuongH-Index: 3
Last. Jun GongH-Index: 7
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BACKGROUND/AIM: We have previously found elevated levels of endoglin (CD105) in the prostate cancer (PC) tissue of men with poor prognosis, compared to men with indolent disease. Herein, we examined whether plasma levels of the soluble form of CD105 (sCD105) differ according to the PC grade at diagnosis. PATIENTS AND METHODS: We measured sCD105 in 73 subjects with biopsy-confirmed PC at the Durham, North Carolina, Veteran Affairs Health System. The association between sCD105 and intermediate/hig...
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#1Calogero CipollaH-Index: 16
#2Giuseppa GraceffaH-Index: 9
Last. Salvatore VieniH-Index: 12
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BACKGROUND/AIM: The aim of this study was to evaluate the current role of frozen section in identifying patients who could benefit from an immediate axillary lymph node dissection (ALND), following the criteria of the ASOCOG Z0011 and IBCSG 23-10 trials. PATIENTS AND METHODS: A retrospective review was performed involving 2,079 patients with early breast cancer who underwent conservative surgery or total mastectomy with sentinel lymph node biopsy. RESULTS: Sensitivity and diagnostic accuracy wer...
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#1Ken-ichiro SakataH-Index: 1
#2Kojiro Maeda (Hokkaido University)H-Index: 1
Last. Junichi Hamada (HSUH: Health Sciences University of Hokkaido)H-Index: 3
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BACKGROUND/AIM: Malignant pleural mesothelioma (MPM) is an intractable cancer, and causes of its malignant transformation are not well known. Adenosine deaminase acting on RNA (ADAR) is an RNA-editing enzyme that converts adenosine into inosine in double-stranded RNAs potentially involved in malignant development. MATERIALS AND METHODS: To examine the role of ADAR1 and ADAR2 in MPM, small interfering RNAs (siRNAs) against ADAR1 or ADAR2 were used. RESULTS: Transfection of siRNA against ADAR2 sup...
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#1Sung-Eun HongH-Index: 5
Last. In-Chul ParkH-Index: 36
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BACKGROUND/AIM: Cancer cells are frequently exposed to microenvironmental stresses, including amino acid deprivation and hypoxia, which are often targeted for cancer therapy. Here, we examined the effect of hypoxia in cysteine-deprived breast cancer cells and the mechanism to counteract the hypoxia effect. MATERIALS AND METHODS: Cell death was determined by annexin V-FITC and propidium iodide staining. Expression of mRNAs and proteins was determined by reverse transcription polymerase chain reac...
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#2Takero HirataH-Index: 3
Last. M. UemuraH-Index: 18
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BACKGROUND: The present study aimed to estimate geometric changes in applicators and prostate over 3 days in patients with high-dose-rate brachytherapy (HDR-BT) and to assess the need for daily replanning. PATIENTS AND METHODS: This study retrospectively investigated 18 patients who underwent HDR-BT as monotherapy from February 2016 to October 2018. RESULTS: Without replanning, the planning target volume coverage significantly worsened on day 2 (p<0.001) and day 3 (p=0.003). The minimum dose dis...
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BACKGROUND/AIM: Radiotherapy for soft tissue sarcomas (STS) of the hand is thought to be associated with poor function. The aim of this study was to compare the long-term functional outcome in patients with and without radiotherapy. PATIENTS AND METHODS: At long-term follow-up (mean 10+/-5 years), 33 (13 males, 20 female) patients, were alive for review. The mean patient age at surgery was 33+/-17 years and 13 (39%) patients received radiotherapy (mean dose 55+/-6 Gy). RESULTS: Postoperatively, ...
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