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The red blood cell proportion of arachidonic acid relates to shorter leukocyte telomeres in Mediterranean elders: A secondary analysis of a randomized controlled trial

Published on Feb 1, 2018in Clinical Nutrition 6.40
· DOI :10.1016/j.clnu.2018.02.011
Tania-Marisa Freitas-Simoes3
Estimated H-index: 3
Montserrat Cofán24
Estimated H-index: 24
(ISCIII: Instituto de Salud Carlos III)
+ 14 AuthorsAleix Sala-Vila21
Estimated H-index: 21
(ISCIII: Instituto de Salud Carlos III)
Summary Background & aims Shortening of leukocyte telomere length (LTL) is a biomarker of aging. Epidemiologic studies of LTL in relation to dietary fatty acids have reported conflicting results. The red blood cell (RBC) fatty acid status is a valid objective biomarker of long-term dietary intake of C18:2n-6, C18:3n-3 and long-chain n-3 polyunsaturated fatty acids (C20:5n-3 and C22:6n-3). In healthy older individuals, we investigated whether LTL relates to the RBC proportions of the main dietary polyunsaturated fatty acids (PUFA), and to the RBC proportion of arachidonic acid (C20:4n-6), a fatty acid that can generate pro-inflammatory lipid mediators once released from cell membranes. Design Cross-sectional study in 344 subjects (mean age 68.8 y, 68.6% women) who participated in a randomized controlled trial testing whether a diet enriched in walnuts can delay the onset of age-related diseases ( ). At baseline, we assessed LTL by high-throughput quantitative fluorescence and determined fatty acids in RBCs by gas chromatography. Results In multivariate models adjusted for age and gender, the RBC proportions of dietary PUFA were unrelated to LTL. In contrast, the RBC proportion of arachidonic acid inversely related to LTL (regression coefficient [95% confidence interval], −0.10 (−0.19 to −0.01), P = 0.023). Conclusion An increasing proportion of C20:4n-6 in RBCs is associated with shorter telomeres. Further research is needed to investigate the role of this fatty acid and its derived lipid mediators in the aging process.
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  • Citations (1)
Published on Jan 10, 2017in Frontiers in Aging Neuroscience 3.63
Sujatha Rajaram17
Estimated H-index: 17
(LLU: Loma Linda University),
Cinta Valls-Pedret11
Estimated H-index: 11
(ISCIII: Instituto de Salud Carlos III)
+ 18 AuthorsAleix Sala-Vila21
Estimated H-index: 21
(ISCIII: Instituto de Salud Carlos III)
Introduction: An unwanted consequence of population aging is the growing number of elderly at risk of neurodegenerative disorders, including dementia and macular degeneration. As nutritional and behavioral changes can delay disease progression, we designed the Walnuts and Healthy Aging (WAHA) study, a two-center, randomized, 2-year clinical trial conducted in free-living, cognitively healthy elderly men and women. Our interest in exploring the role of walnuts in maintaining cognitive and retinal...
Published on Apr 1, 2016in Metabolism-clinical and Experimental 6.51
Tania-Marisa Freitas-Simoes3
Estimated H-index: 3
Emilio Ros72
Estimated H-index: 72
(ISCIII: Instituto de Salud Carlos III),
Aleix Sala-Vila21
Estimated H-index: 21
(ISCIII: Instituto de Salud Carlos III)
Identifying simple strategies to prevent or delay age-associated pathologies is a major public health concern. Attrition of telomeres, chromatin structures that help maintain genome stability, leads to cell death or senescence. Thus telomere length is a reliable hallmark of biological aging and the risk of developing age-related chronic diseases through common oxidation and inflammation mechanisms. Variability in telomere shortening that is independent of chronological age suggests that it is a ...
Published on Mar 1, 2015in Cell 36.22
Luigi Fontana48
Estimated H-index: 48
(MPG: Max Planck Society),
Linda Partridge97
Estimated H-index: 97
(MPG: Max Planck Society)
Reduced food intake, avoiding malnutrition, can ameliorate aging and aging-associated diseases in invertebrate model organisms, rodents, primates, and humans. Recent findings indicate that meal timing is crucial, with both intermittent fasting and adjusted diurnal rhythm of feeding improving health and function, in the absence of changes in overall intake. Lowered intake of particular nutrients rather than of overall calories is also key, with protein and specific amino acids playing prominent r...
Published on Oct 1, 2014in Nutrition 3.59
Undurti N. Das29
Estimated H-index: 29
Published on Mar 1, 2013in Journal of Lipid Research 4.74
Lotta Kilpinen6
Estimated H-index: 6
(Finnish Red Cross),
Feven Tigistu-Sahle4
Estimated H-index: 4
(UH: University of Helsinki)
+ 8 AuthorsReijo Käkelä23
Estimated H-index: 23
(UH: University of Helsinki)
Human mesenchymal stem/stromal cells (hMSC) are increasingly used in advanced cellular therapies. The clinical use of hMSCs demands sequential cell expansions. As it is well established that membrane glycerophospholipids (GPL) provide precursors for signaling lipids that modulate cellular functions, we studied the effect of the donor's age and cell doublings on the GPL profile of human bone marrow MSC (hBMSC). The hBMSCs, which were harvested from five young and five old adults, showed clear com...
Published on Feb 1, 2013in Brain Behavior and Immunity 6.17
Janice K. Kiecolt-Glaser93
Estimated H-index: 93
(OSU: Ohio State University),
Elissa S. Epel68
Estimated H-index: 68
(UCSF: University of California, San Francisco)
+ 6 AuthorsElizabeth H. Blackburn91
Estimated H-index: 91
(UCSF: University of California, San Francisco)
Abstract Shorter telomeres have been associated with poor health behaviors, age-related diseases, and early mortality. Telomere length is regulated by the enzyme telomerase, and is linked to exposure to proinflammatory cytokines and oxidative stress. In our recent randomized controlled trial, omega-3 ( n -3) polyunsaturated fatty acid (PUFA) supplementation lowered the concentration of serum proinflammatory cytokines. This study assessed whether n -3 PUFA supplementation also affected leukocyte ...
Published on Jan 1, 2013in Epidemiologic Reviews 6.46
Jason L. Sanders18
Estimated H-index: 18
A. B. Newman140
Estimated H-index: 140
(University of Pittsburgh)
Telomeres are nucleoprotein caps flanking DNA. They are shortened by cell division and oxidative stress and are lengthened by the enzyme telomerase and DNA exchange during mitosis. Short telomeres induce cellular senescence. As an indicator of oxidative stress and senescence (2 processes thought to be fundamental to aging), telomere length is hypothesized to be a biomarker of aging. This hypothesis has been tested for more than a decade with epidemiologic study methods. In cross-sectional studie...
Published on Aug 1, 2011in British Journal of Nutrition 3.32
Aleix Sala-Vila21
Estimated H-index: 21
William S. Harris74
Estimated H-index: 74
+ 6 AuthorsEmilio Ros72
Estimated H-index: 72
The omega-3 index, defined as the sum of EPA and DHA in erythrocyte membranes expressed as a percentage of total fatty acids, has been proposed as both a risk marker and risk factor for CHD death. A major determinant of the omega-3 index is EPA þ DHA intake, but the impact of other dietary fatty acids has not been investigated. In a cross-sectional study on 198 subjects (102 men and 96 women, mean age 66 years) at high cardiovascular risk living in Spain, the country with low rates of cardiac de...
Published on Sep 1, 2008in Progress in Lipid Research 12.54
Leanne Hodson5
Estimated H-index: 5
(Churchill Hospital),
Skeaff Cm1
Estimated H-index: 1
(University of Otago),
Barbara A. Fielding49
Estimated H-index: 49
(Churchill Hospital)
Accurate assessment of fat intake is essential to examine the relationships between diet and disease risk but the process of estimating individual intakes of fat quality by dietary assessment is difficult. Tissue and blood fatty acids, because they are mainly derived from the diet, have been used as biomarkers of dietary intake for a number of years. We review evidence from a wide variety of cross-sectional and intervention studies and summarise typical values for fatty acid composition in adipo...
Andrés Canela10
Estimated H-index: 10
Elsa Vera16
Estimated H-index: 16
+ 1 AuthorsMaria A. Blasco83
Estimated H-index: 83
A major limitation of studies of the relevance of telomere length to cancer and age-related diseases in human populations and to the development of telomere-based therapies has been the lack of suitable high-throughput (HT) assays to measure telomere length. We have developed an automated HT quantitative telomere FISH platform, HT quantitative FISH (Q-FISH), which allows the quantification of telomere length as well as percentage of short telomeres in large human sample sets. We show here that t...
Cited By1
Published on Jan 1, 2019in Ageing Research Reviews 10.39
Sergio Davinelli14
Estimated H-index: 14
(UNIMOL: University of Molise),
Antonia Trichopoulou25
Estimated H-index: 25
+ 2 AuthorsGiovanni Scapagnini27
Estimated H-index: 27
(UNIMOL: University of Molise)
Abstract The Mediterranean diet (MD) is a gold standard for nutrition and the most evidence-based diet to delay the onset of age-associated pathologies. Telomeres are the heterochromatic repeat regions found at the ends of eukaryotic chromosomes, whose length is considered a reliable hallmark of biological ageing. Telomere shortening is, at least in part, a modifiable factor and there is evidence that adherence to the MD is associated with longer telomeres. Data from several studies indicate an ...