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Cancer immunotherapy in 2017: The breakthrough of the microbiota

Published on Feb 1, 2018in Nature Reviews Immunology44.019
· DOI :10.1038/nri.2018.4
Guido Kroemer197
Estimated H-index: 197
,
Laurence Zitvogel115
Estimated H-index: 115
Sources
Abstract
In 2017, epidemiological studies in humans and experiments in mouse models showed that the intestinal microbiota determines the effectiveness of anticancer immunotherapies. As such the microbiota offers new prognostic biomarkers and shows promise as a target for future antineoplastic treatments.
  • References (11)
  • Citations (23)
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References11
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Colorectal cancers comprise a complex mixture of malignant cells, nontransformed cells, and microorganisms. Fusobacterium nucleatum is among the most prevalent bacterial species in colorectal cancer tissues. Here we show that colonization of human colorectal cancers with Fusobacterium and its associated microbiome—including Bacteroides , Selenomonas , and Prevotella species—is maintained in distal metastases, demonstrating microbiome stability between paired primary and metastatic tumors. In sit...
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