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Nature Reviews Immunology
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44.02
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#1Laure-Anne TeuwenH-Index: 4
#2Vincent GeldhofH-Index: 5
Last. Peter CarmelietH-Index: 141
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On the basis of emerging evidence from patients with COVID-19, we postulate that endothelial cells are essential contributors to the initiation and propagation of severe COVID-19. Here, we discuss current insights into the link between endothelial cells, viral infection and inflammatory changes and propose novel therapeutic strategies.
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Ramanan et al. describe a maternally transmitted variance in colonic populations of regulatory T cells that depends on IgA levels in maternal milk.
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#1Nicholas M. Adams (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 6
#2Simon Grassmann (MSK: Memorial Sloan Kettering Cancer Center)
Last. Joseph C. Sun (Cornell University)H-Index: 36
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One of the hallmarks of the vertebrate adaptive immune system is the prolific expansion of individual cell clones that encounter their cognate antigen. More recently, however, there is growing evidence for the clonal expansion of innate lymphocytes, particularly in the context of pathogen challenge. Clonal expansion not only serves to amplify the number of specific lymphocytes to mount a robust protective response to the pathogen at hand but also results in selection and differentiation of the r...
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#1Matthew D. Park (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
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#1Alessandra Soares-Schanoski (ISMMS: Icahn School of Medicine at Mount Sinai)
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#1Bérengère Salomé (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 2
#2Zafar Mahmood (ISMMS: Icahn School of Medicine at Mount Sinai)
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#1Luke A. J. O'Neill (Trinity College, Dublin)H-Index: 106
#2Mihai G. Netea (University of Bonn)
Bacillus Calmette–Guerin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19. Could the BCG vaccine be used to bridge the gap until a specific COVID-19 vaccine is developed? Luke O’Neil...
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The COVID-19 pandemic caused by infection with SARS-CoV-2 has led to more than 200,000 deaths worldwide. Several studies have now established that the hyperinflammatory response induced by SARS-CoV-2 is a major cause of disease severity and death in infected patients. Macrophages are a population of innate immune cells that sense and respond to microbial threats by producing inflammatory molecules that eliminate pathogens and promote tissue repair. However, a dysregulated macrophage response can...
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A new study shows how myeloid-derived suppressor cells paralyse CD8+ T cell effector functions by transferring the metabolite methylglyoxal directly into the T cell cytosol, where it depletes essential amino acids.
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#1William C. Gause (RU: Rutgers University)H-Index: 54
#2Carla V. Rothlin (Yale University)H-Index: 25
Last. P’ng Loke (NIH: National Institutes of Health)H-Index: 1
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Type 2 immune responses operate under varying conditions in distinct tissue environments and are crucial for protection against helminth infections and for the maintenance of tissue homeostasis. Here we explore how different layers of heterogeneity influence type 2 immunity. Distinct insults, such as allergens or infections, can induce type 2 immune responses through diverse mechanisms, and this can have heterogeneous consequences, ranging from acute or chronic inflammation to deficits in immune...
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Top fields of study
Innate immune system
Immunology
T cell
Biology
Immune system
Cell biology