Guido Kroemer
Pierre-and-Marie-Curie University
Publications 1320
#1Lorenzo GalluzziH-Index: 94
#2Andreas LinkermannH-Index: 36
Last.Guido KroemerH-Index: 197
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Abstract Malignant transformation, tumor progression and resistance to cancer therapy often occur in the context of disabled cell death signaling. Here we describe the major mechanisms of cell death regulation in mammalian cells and discuss the pathophysiologic and therapeutic implications of their deregulation in the course of oncogenesis.
#1Didac Carmona-Gutierrez (University of Graz)H-Index: 34
#2Andreas Zimmermann (University of Graz)H-Index: 10
Last.Frank Madeo (University of Graz)H-Index: 77
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Ageing constitutes the most important risk factor for all major chronic ailments, including malignant, cardiovascular and neurodegenerative diseases. However, behavioural and pharmacological interventions with feasible potential to promote health upon ageing remain rare. Here we report the identification of the flavonoid 4,4′-dimethoxychalcone (DMC) as a natural compound with anti-ageing properties. External DMC administration extends the lifespan of yeast, worms and flies, decelerates senescenc...
9 CitationsSource
#1Peng Liu (Sorbonne)H-Index: 38
#2Liwei Zhao (Sorbonne)H-Index: 5
Last.Guido KroemerH-Index: 197
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Immunogenic cell death (ICD) converts dying cancer cells into a therapeutic vaccine and stimulates antitumor immune responses. Here we unravel the results of an unbiased screen identifying high-dose (10 µM) crizotinib as an ICD-inducing tyrosine kinase inhibitor that has exceptional antineoplastic activity when combined with non-ICD inducing chemotherapeutics like cisplatin. The combination of cisplatin and high-dose crizotinib induces ICD in non-small cell lung carcinoma (NSCLC) cells and effec...
10 CitationsSource
#1Luigi Maiuri (European Institute)H-Index: 8
#2Valeria R. Villella (University of Eastern Piedmont)
Last.Guido KroemerH-Index: 197
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Familial loss-of-function mutations of the gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) channel protein cause cystic fibrosis (CF), the most frequent inherited life-threatening disease in the Caucasian population. A recent study indicates that the gluten/gliadin-derived peptide (P31–43) can cause CFTR inhibition in intestinal epithelial cells, thus causing a local stress response that contributes to the immunopathology of celiac disease (CD). Accordingly, an inc...
#1Peng LiuH-Index: 38
#2Liwei ZhaoH-Index: 5
Last.Guido KroemerH-Index: 197
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The original version of this Article contained an error in the spelling of the author Lin Xia, which was incorrectly given as Xia Lin. This has now been corrected in both the PDF and HTML versions of the Article.
#1Reshmi Tripathi (Cincinnati Children's Hospital Medical Center)H-Index: 1
#2Vishnu Modur (Cincinnati Children's Hospital Medical Center)H-Index: 1
Last.Kakajan Komurov (Cincinnati Children's Hospital Medical Center)H-Index: 16
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ABSTRACTAnti-tumor immune responses impede tumor formation, and cancers have evolved many mechanisms of immune evasion. Confirming earlier findings, we show that human tumors with high chromosomal ...
#1Jenny Sprooten (Katholieke Universiteit Leuven)H-Index: 1
#2Jolien Ceusters (Katholieke Universiteit Leuven)H-Index: 1
Last.Abhishek D. Garg (Katholieke Universiteit Leuven)H-Index: 39
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ABSTRACTDendritic- cells (DCs) have received considerable attention as potential targets for the development of anticancer vaccines. DC-based anticancer vaccination relies on patient-derived DCs pu...
1 CitationsSource
#1Elisa Elena Baracco (French Institute of Health and Medical Research)H-Index: 7
#2Gautier Stoll (French Institute of Health and Medical Research)H-Index: 9
Last.Guido Kroemer (French Institute of Health and Medical Research)H-Index: 197
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ABSTRACTMouse cancers lacking the expression of annexin A1 (ANXA1) fail to respond to immunogenic chemotherapies. This has been initially explained by the requirement of extracellular ANXA1 (which ...
#1Wei Xie (UPMC: Pierre-and-Marie-Curie University)
#2Sabrina Forveille (UPMC: Pierre-and-Marie-Curie University)H-Index: 5
Last.Oliver Kepp (UPMC: Pierre-and-Marie-Curie University)H-Index: 27
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ABSTRACTSystemic treatment with the active transcription inhibitor lurbinectedin aims at inducing tumor cell death in hyperproliferative neoplasms. Here we show that cell death induced by lurbinect...
#1José Manuel Bravo-San Pedro (University of Paris)H-Index: 1
#2Valentina Sica (University of Paris)H-Index: 11
Last.Guido Kroemer (CAS: Chinese Academy of Sciences)H-Index: 197
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ABSTRACTDBI/ACBP (diazepam binding protein, acyl-CoA binding protein) participates in the regulation of fatty acid metabolism when it is localized within cells, whereas outside of cells it acts as ...
1 CitationsSource