Original paper
Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
Abstract
Integrating epigenetic data with genome-wide association study (GWAS) results can reveal disease mechanisms. The genome sequence itself also shapes the epigenome, with CpG density and transcription factor binding sites (TFBSs) strongly encoding the DNA methylome. Therefore, genetic polymorphism impacts on the observed epigenome. Furthermore, large genetic variants alter epigenetic signal dosage. Here, we identify DNA methylation variability...
Paper Details
Title
Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci
Published Date
Jan 2, 2018
Journal
Volume
9
Issue
1
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Notes
History