Modifying bone mineral density, physical function, and quality of life in children with acute lymphoblastic leukemia

Background The early effects of childhood acute lymphoblastic leukemia (ALL) include decreased physical function, bone mineral density (BMD/g/cm 2 ), and health‐related quality of life (HRQL). We assessed the capacity of a physical therapy and motivation‐based intervention, beginning after diagnosis and continuing through the end of treatment, to positively modify these factors. Procedure A 2.5‐year randomized controlled trial of 73 patients...