Steady-State Clozapine and Norclozapine Pharmacokinetics in Maori and European Patients

BackgroundClozapine is the most effective drug for treatment-resistant schizophrenia, but its use is limited by toxicity. Because ethnicity has been reported to affect clozapine metabolism, we compared its steady state pharmacokinetics in New Zealand Maori and European patients.MethodsClozapine and norclozapine steady state bioavailability was assessed over 24 h under fasting and fed conditions in 12 Maori and 16 European patients treated for...