Differential gene expression elicited by children in response to the 2015–16 live attenuated versus inactivated influenza vaccine

In recent influenza seasons, the live attenuated influenza vaccine (LAIV) has not demonstrated the same level of vaccine effectiveness as that observed among children who received the inactivated influenza vaccine (IIV). To better understand this difference, this study compared the mRNA sequencing transcription profile (RNA seq) in children who received either IIV or LAIV. Children 3–17 years of age receiving quadrivalent influenza vaccine were...